ClotriMazole Related CoMpound A

ClotriMazole Related CoMpound A - Names and Identifiers

Name	(2-chlorophenyl)(diphenyl)methanol
Synonyms	ClotriMazole IMpurity A o-chlorotriphenylmethanol Clotrimazole EP Impurity A ClotriMazole Related CoMpound A (2-chlorophenyl)(diphenyl)methanol Clotrimazole EP Impurity A(USP RC A) Benzenemethanol, 2-chloro-α,α-diphenyl- Clotrimazole Impurity 1(Clotrimazole EP Impurity A)
CAS	66774-02-5
InChI	InChI=1/C19H15ClO/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,21H

ClotriMazole Related CoMpound A - Physico-chemical Properties

Molecular Formula	C19H15ClO
Molar Mass	294.77
Density	1.216g/cm³
Melting Point	91-92 °C(Solv: acetic acid (64-19-7))
Boling Point	447.6°C at 760 mmHg
Flash Point	224.5°C
Vapor Presure	8.49E-09mmHg at 25°C
Appearance	Form Solid, color White to Pale Yellow
pKa	12.36±0.29(Predicted)
Storage Condition	Refrigerator
Refractive Index	1.627
Physical and Chemical Properties	Chemical properties crystallization. Melting point 84-86 ℃.
Use	Intermediates of clotrimazole.

ClotriMazole Related CoMpound A - Risk and Safety

HS Code

2906290000

ClotriMazole Related CoMpound A - Upstream Downstream Industry

Raw Materials	1-Chloro-2-(dichlorophenylMethyl)benzene Clotrimazole 1-Chloro-2-iodobenzene (2-Chlorophenyl)magnesium bromide Methyl 2-chlorobenzoate Benzophenone Benzene
Downstream Products	(2-Chlorophenyl)phenyl-methanone

ClotriMazole Related CoMpound A - Production method

Use o-chlorobenzoic acid and ethanol to esterify with the participation of sulfuric acid or p-toluenesulfonic acid to generate ethyl o-chlorobenzoate, and then it is condensed with phenyl magnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl) diphenylmethanol magnesium salt, which is hydrolyzed with sulfuric acid to obtain the product.

Last Update：2024-04-10 22:29:15