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Clovis CO-1686

CO-1686

CAS: 1374640-70-6

Molecular Formula: C27H28F3N7O3

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Clovis CO-1686 - Names and Identifiers

Name CO-1686
Synonyms CO1686
CNX-419
CO-1686
AVL-301
ROCILETINIB
Clovis CO-1686
N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide
CAS 1374640-70-6

Clovis CO-1686 - Physico-chemical Properties

Molecular FormulaC27H28F3N7O3
Molar Mass555.55
Density1.372±0.06 g/cm3(Predicted)
Melting Point202 - 205°C (dec.)
AppearanceForm Solid, color Off-White
pKa13.23±0.70(Predicted)
Storage ConditionAmber Vial, -20°C Freezer, Under inert atmosphere
MDLMFCD26793864
Physical and Chemical PropertiesBioactive Rociletinib (CO-1686, AVL-301) is an irreversible, selective inhibition of mutant EGFR, acting on EGFRL858R/T790M and EGFRWT in cell-free assays with Ki of 21.5 nM and 303.3 nM, respectively. Phase 2.

Clovis CO-1686 - Risk and Safety

Risk CodesR23 - Toxic by inhalation
R25 - Toxic if swallowed
R36 - Irritating to the eyes
Safety Description24 - Avoid contact with skin.
HS Code29335990

Clovis CO-1686 - Upstream Downstream Industry

Raw MaterialsN-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediaMine
N-BOC-M-PHENYLENEDIAMINE
2,4-Dichloro-5-trifluoromethylpyrimidine
CO-1686 intermediate 1
tert-butyl (3-((2-chloro-5-(trifluoroMethyl)pyriMidin-4-yl)aMino)phenyl)carbaMate
N-(4-aminophenyl)acrylamide
1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone
5-Fluoro-2-nitroanisole
3-Chloropropionyl chloride
Acryloyl chloride

Clovis CO-1686 - Introduction

CO-1686 (AVL-301) is an irreversible, mutation-selective EGFR inhibitor that acts on EGFRL858R/T790M and EGFRWT with a Ki of 21.5 nM and 303.3 nM, respectively. Phase 2.
Last Update：2022-10-16 17:13:42
Clovis CO-1686
Supplier List
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: CO-1686 (AVL-301) Visit Supplier Webpage Request for quotation
CAS: 1374640-70-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: CO-1686 (AVL-301) Visit Supplier Webpage Request for quotation
CAS: 1374640-70-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
Clovis CO-1686
Raw Materials for Clovis CO-1686
N-BOC-M-PHENYLENEDIAMINE
CO-1686 intermediate 1
tert-butyl (3-((2-chloro-5-(trifluoroMethyl)pyriMidin-4-yl)aMino)phenyl)carbaMate
N-(4-aminophenyl)acrylamide
5-Fluoro-2-nitroanisole
3-Chloropropionyl chloride
Acryloyl chloride
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