Corey lactone

Corey lactone - Names and Identifiers

Name	Corey lactone
Synonyms	Coreylactone Corey lactone Corey lactone THP 2H-Cyclopenta[b]furan-2-one hexahydro-4-(hydroxyMethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]- (3aR,4S,5R,6aS)-4-(hydroxymethyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one (3aR,4S,5R,6aS)-Hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-cyclopenta[b]furan-2-one 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)- 2H-Cyclopenta[B]Furan-2-One, Hexahydro-4-(Hydroxymethyl)-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (3Ar,4S,5R,6As)- 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)- 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)- (9CI)
CAS	69222-61-3
InChI	InChI=1/C13H20O5/c14-7-9-8-5-12(15)17-10(8)6-11(9)18-13-3-1-2-4-16-13/h8-11,13-14H,1-7H2/t8-,9-,10+,11-,13?/m1/s1

Corey lactone - Physico-chemical Properties

Molecular Formula	C13H20O5
Molar Mass	256.29
Density	1.26
Boling Point	454.2±45.0 °C(Predicted)
pKa	14.79±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.531

Corey lactone - Introduction

Corey lactone(Corey lactone) is an organic compound with the chemical formula C13H20O3. It is a loose white or light yellow crystal powder. Corey lactone is an important derivative of allyl alcohol with a variety of applications.

Corey lactone are widely used as synthetic intermediates in medicinal chemistry and organic synthesis. It can be used to synthesize biologically active compounds, such as antibiotics, hormones, enzyme inhibitors, etc. In addition, Corey lactone is also used as a catalyst for the synthesis of complex natural product molecules and organic synthesis reactions.

The preparation method of Corey lactone is usually completed by reacting allyl alcohol with anhydride under acidic conditions. Specifically, allyl alcohol and anhydride are added to the reactants in a molar ratio of 1:1, and the intermediate produced by the reaction is hydrolyzed by acid to obtain Corey lactone.

Regarding the safety information of Corey lactone, it is a low-toxic compound, but it still needs to be paid attention to normal laboratory handling and storage. Avoid skin contact and inhalation, and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses, during operation. In addition, contact with chemical reagents such as oxidants and strong acids should be avoided to avoid dangerous reactions.

Last Update：2024-04-09 21:54:55