Cyclohexanone, 4-ethyl-2,6-bis(3-pyridinylmethylene)-, (2E,6E)-

Name	MCB-613
Synonyms	MCB-613 CS-2522 4-ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone (2E,6E)-4-Ethyl-2,6-bis(3-pyridinylmethylene)cyclohexanone Cyclohexanone, 4-ethyl-2,6-bis(3-pyridinylmethylene)-, (2E,6E)- (2E,6E)-4-ethyl-2,6-bis(pyridin-3-ylmethylidene)cyclohexan-1-one
CAS	1162656-22-5

Molecular Formula	C20H20N2O
Molar Mass	304.39
Density	1.159±0.06 g/cm3(Predicted)
Boling Point	510.4±50.0 °C(Predicted)
Solubility	DMSO: 10 mg/mL
pKa	4.36±0.12(Predicted)
Storage Condition	Sealed in dry,Room Temperature

Last Update：2024-01-02 23:10:35

preparation	with 3-pyridinecarboxaldehyde and p-ethylcyclohexanone as raw materials, bipyridine α was obtained by Claisen-Schmidt condensation reaction, Β-unsaturated ketone intermediate 4-ethyl-2, 6-bis (pyridine-3-methylene) cyclohexanone. Dry HCl was used as the catalyst for the condensation reaction. The operation was simple and the yield was over 85%.
biological activity	MCB-613 is a potent steroid receptor coactivator (SRC) small molecule "stimulators" (SMS), super-stimulate the transcriptional activity of SRCs. MCB-613 increases the interaction of SRC with other co-activators and significantly induces ER stress in combination with the production of reactive oxygen species (ROS). MCB-613 is an SMS that targets oncogenes as anticancer drugs by overstimulating the SRC oncogenic program.
Cell Line:	MDA-MB-231 cells HeLa cells SRC-3 KO and WT HeLa cells
Concentration:	6 μM; 8 μM 2 μM; 4 μM; 6 μM; 8 μM; 10 μM 3 μM; 4 μM; 5 μM; 6 μM; 7 μM
Incubation Time:	24 hours 24 hours 24 hours
Result:	Increased MMP13 mRNA expression. Induced the p-eIF2α, p-IRE1α, and ATF-4 protein expression. Decreased SRC-3 KO and WT HeLa cell viability. Inhibited tumor growth in vivo.
Animal Model:	MCF-7 breast cancer mouse xenograft model (athymic nude mice by injecting MCF-7 cells into mammary fat pads)
Dosage:	20 mg/kg
Administration:	Intravenous injection; 20 mg/kg; 3 times/week; 7 weeks

Last Update：2024-04-09 20:52:54

Product Name: MCB-613 Visit Supplier Webpage Request for quotation
CAS: 1162656-22-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: MCB-613 Visit Supplier Webpage Request for quotation
CAS: 1162656-22-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

Cyclohexanone, 4-ethyl-2,6-bis(3-pyridinylmethylene)-, (2E,6E)- Request for Quotation