Cyclosporin A, 9-(N-methyl-L-isoleucine)-

Name	(melle-4)cyclosporin
Synonyms	NIM811 Sdz nim811 Sdz nim 811 Sdz-nim-811 (melle-4)cyclosporin Cyclosporin A, 9-(N-methyl-L-Isoleu) 9-(N-Methyl-L-isoleucine)cyclosporin a Cyclosporin A, 9-(N-methyl-L-isoleucine)-
CAS	143205-42-9

Molecular Formula	C62H111N11O12
Molar Mass	1202.64
Density	1.018±0.06 g/cm3(Predicted)
Boling Point	1293.6±65.0 °C(Predicted)
pKa	13.32±0.70(Predicted)
Storage Condition	-20°C
In vitro study	NIM811 induces a concentration-dependent reduction of HCV RNA in the replicon cells with an IC 50 of 0.66 μM at 48 h. In addition, the combination of NIM811 with alpha IFN significantly enhances anti-HCV activities without causing any increase of cytotoxicity. NIM811 blocks the mitochondrial permeability transition induced by calcium and inorganic phosphate.
In vivo study	NIM811 prevents mitochondrial depolarization thereby attenuates liver injury, stimulates regeneration and improves liver function and survival.

Last Update：2024-01-02 23:10:35

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CAS: 143205-42-9
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QQ: 3008007409

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Cyclosporin A, 9-(N-methyl-L-isoleucine)-

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