D-alpha-生育酚醋酸酯
D-alpha-Tocopheryl acetate
CAS: 58-95-7
Molecular Formula: C31H52O3
D-alpha-生育酚醋酸酯 - Names and Identifiers
| Name | D-alpha-Tocopheryl acetate |
| Synonyms | D-alpha-Tocopherylacetate D-alpha-Tocopheryl acetate (R,R,R)-α-TocopherylAcetate (2R,4'R,8'R)-α-TocopherolAcetate (2R,4'R,8'R)-α-TocopherylAcetate D-alpha-TocopherylacetateVitamineE-acetate 2,5,7,8-TetraMethyl-2-(4,8,12-triMethyltridecyl)-6-chroManolAcetate (2R)-3,4-Dihydro-2,5,7,8-tetraMethyl-2-[(4R,8R)-4,8,12-triMethyltridecyl]-2H-1-benzopyran-6-ol6-Acetate |
| CAS | 58-95-7 |
| EINECS | 200-405-4 |
D-alpha-生育酚醋酸酯 - Physico-chemical Properties
| Molecular Formula | C31H52O3 |
| Molar Mass | 472.75 |
| Density | 0.953 g/mL at 25 °C(lit.) |
| Melting Point | ~25 °C(lit.) |
| Boling Point | 224 °C0.3 mm Hg(lit.) |
| Specific Rotation(α) | +3.03 (c, 5 in EtOH) |
| Flash Point | >230 °F |
| Water Solubility | <0.1 g/100 mL at 17 ºC |
| Solubility | Easily soluble in oil, fat, acetone, chloroform, ethanol, ether and other fat solvents, almost insoluble in water |
| Appearance | oily |
| Storage Condition | 2-8℃ |
| Refractive Index | 0 |
| MDL | MFCD00072052 |
| Physical and Chemical Properties | Chemical properties of yellowish or yellow transparent viscous liquid, almost odorless, easy to oxidize light color gradient deep. Relative density d2540.950, refractive index (n20D)1.495chemical book0-1.4972, ethanol solution of this product has maximum absorption at 284nm ± 1nm wavelength. This product is soluble in oil, fat, ethanol, acetone, ether and chloroform, insoluble in water. |
| Use | Use tocopheryl acetate, also known as vitamin E acetate, is a common vitamin supplement. It is an ester of acetic acid and tocopherol (vitamin E) and is commonly used in skin care products such as skin creams. Tocopherol acetate is not oxidized and can penetrate the skin into living cells, where about 5% is converted to free tocopherol, providing a beneficial antioxidant effect. Because the phenolic hydroxyl groups are blocked, tocopherol acetate is used as a substitute for tocopherol itself, providing a less acidic, longer shelf life product. It is believed that once absorbed by the skin, acetate is slowly hydrolyzed to regenerate tocopherols, providing sun protection. |
D-alpha-生育酚醋酸酯 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
D-alpha-生育酚醋酸酯 - Reference
| Reference Show more | Ding Li, Ouyang Wu Qing. Quality evaluation of compound vitamin Nanoemulsion injection [J]. Progress in animal medicine, 2020,41(11):79-83. |
D-alpha-生育酚醋酸酯 - Production method of α-tocopherol acetate
from Baidu Library
Application (patent) number:
CN200380108718.2
Public/Announcement Number:
CN1738810 A
applicant (patent):
DSM Intellectual Property Asset Management, Inc.
inventor:
Werner Bonatti Claus ditel , Thomas Thomas pbst Liza gilatti
cited:
Abstract:
The present invention relates to a novel process for the production of α-tocopherol acetate comprising, in the presence of a catalyst of the formula Mn (R1SO3-)n, 6-trimethylhydroquinone-1-acetate with phytol (R = OH in Formula IV), isophytol (R = OH in Formula III) or (ISO) selected from the following formula III and IV the phytol derivative is reacted and, if necessary, any 3-phytonyl-2, 5, 6-trimethylhydroquinone -1-acetate obtained as an intermediate reaction product is cyclized, to produce α-tocopherol acetate, in formulae III and IV representing (ISO) phytol derivatives, R = C2-5 alkanoyloxy, benzoyloxy, methanesulfonyloxy, benzenesulfonyloxy or tosyloxy, in the formula Mn (R1SO3-)n, Mn is silver, copper, gallium, hafnium or rare earth metal cations, n is the valence of the cation Mn, R1 is fluoro, C1-8 perfluoroalkyl or perfluoro
.Last Update：2024-01-02 23:10:35
D-alpha-生育酚醋酸酯 - Preparation of Tocopheryl succinate, tocopheryl acetate
from hownet
Author:
Abstract:
vitamin E (tocopherol) deep processing products such as tocopherol succinate, tocopherol acetate chemical stability, in many aspects of efficacy and ease of use is the improvement of vitamin E, not only can make up for its lack of application, it can also expand its application areas. So far, the deep processing of vitamin E is mainly focused on the use of the same type of tocopherol raw materials. In this paper, the preparation process of tocopherol succinate and tocopherol acetate was studied by using natural tocopherol and synthetic tocopherol as raw materials. Experimental study found that... view all
Key words:
Tocopheryl succinate preparation process tocopherol acetate vitamin E
degree level:
MSc
degree year:
2008
DOI:
10.7666/d.d051323
cited:
Last Update：2023-08-16 22:09:50
D-alpha-生育酚醋酸酯 - Preparation of α-tocopheryl acetate
Author:
Wu Chunyan , Duan Zhengkang , Yu Jian
Abstract:
natural α-tocopheryl acetate is widely used in medicine, food, cosmetics, feed and other aspects such as for the protection of periodontal tissue, promote ulcer healing and fight inflammation, not easily affected by air, light, UV oxidation, compared with natural α-tocopherol has better stability. There are few reports about the production of α-tocopherol acetate in the industry in China. The reports in the laboratory process are based on the esterification reaction of triethylamine or concentrated hydrochloric acid/zinc oxide as catalyst, but the reaction time is too long, other impurities in the reaction are difficult to remove, and the esterification rate of α-tocopherol acetate is not high, which makes it difficult to realize industrialization.
Key words:
p-toluenesulfonic acid α-tocopheryl acetate esterification
meeting name:
The Third National Annual Meeting of chemical engineering and biochemical engineering
meeting place:
Nanning, Guangxi, China
cited:
Last Update：2023-08-16 22:09:50
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