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DEPOCYT (cytarabine)

cytosine-1-beta-D-arabinofuranoside

CAS: 147-94-4

Molecular Formula: C9H13N3O5

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DEPOCYT (cytarabine) - Names and Identifiers

Name cytosine-1-beta-D-arabinofuranoside
Synonyms Ara-cell
cytarabine
cytrarabine
arabinocytidine
cytosine arabinoside
DEPOCYT (cytarabine)
Cytarabine　for　Injection
1-b-D-Arabinofuranosylcytosine
cytosine-1-beta-D-arabinofuranoside
Cytosine 1-beta-D-arabinofuranoside
4-amino-1-pentofuranosylpyrimidin-2(1H)-one
4-amino-1-(D-arabinofuranosyl)pyrimidin-2(1H)-one
4-amino-1-beta-d-arabinofuranosyl-2(1h)-pyrimidinone
4-amino-1-(beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
N-(2-oxo-2,3-dihydropyrimidin-4-yl)-D-arabinofuranosylamine
4-amino-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
4-aMino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2-dihydropyriMidin-2-one
4-AMino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinoneArabinocytidineCytosine beta-D-ArabinofuranosideAra-C
CAS 147-94-4
EINECS 205-705-9
InChI InChI=1/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6+,7?,8-/m1/s1
InChIKey UHDGCWIWMRVCDJ-STUHELBRSA-N

DEPOCYT (cytarabine) - Physico-chemical Properties

Molecular FormulaC9H13N3O5
Molar Mass243.22
Density1.3686 (rough estimate)
Melting Point214 °C
Boling Point386.09°C (rough estimate)
Specific Rotation(α)D24 +153° (c = 0.5 in water)
Flash Point283.8°C
Water Solubilityalmost transparency
Solubility Soluble in water, partially soluble in methanol, almost insoluble in ether,
Vapor Presure3.5E-14mmHg at 25°C
AppearanceWhite crystal
ColorPrisms from EtOH (aq)
Maximum wavelength(λmax)['272nm(H2O)(lit.)']
Merck14,2784
BRN89175
pKapKa 4.3 (Uncertain)
Storage Condition2-8°C
StabilityStable for 1 year as supplied from date of purchase. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
SensitiveEasily absorbing moisture
Refractive Index1.5100 (estimate)
MDLMFCD00066487
Physical and Chemical Properties

UseFor all kinds of acute leukemia.

DEPOCYT (cytarabine) - Risk and Safety

Risk CodesR43 - May cause sensitization by skin contact
R63 - Possible risk of harm to the unborn child
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety DescriptionS36/37 - Wear suitable protective clothing and gloves.
S37/39 - Wear suitable gloves and eye/face protection
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSHA5425000
FLUKA BRAND F CODES10-23
HS Code29349990
ToxicityLD50 oral in rat: > 5gm/kg

DEPOCYT (cytarabine) - Reference

Reference
Show more
1. Huang Xiuqing, Zhao Xiaohua, Xu Jian, Zhou Chun. Mechanism of L-stephandrine inhibiting Tau protein hyperphosphorylation in improving cognitive symptoms of Parkinson's disease [J]. Chinese Modern Applied Pharmacy, 2018,35(05):648-652.
2. Ke Hong, Wu Lun, Wang Li. Effect of Epimedium Extract on Cell Biological Characteristics of Acute Myeloid Leukemia SCID Mouse Model [J]. Chinese Traditional Chinese Medicine Emergency, 2018.
3. Ji Xian, Yan Gao Jian, Zhang Lei, Cao Jiang Su, Hu Jiabo. Effects of conditioned medium of human embryonic stem cell derived neurospheres on proliferation and migration of rat Schwan cells [J]. Journal of Jiangsu University (Medical Edition) 2019 29(03):189-194.
4. Wang Zhiqing. Efficacy Analysis and Mechanism of Qifu Fuzheng Mixture Combined with Low Dose Traditional Chemotherapy Regimen in Treating Elderly Acute Myeloid Leukemia (Non-M3) [D]. Nanjing university of traditional Chinese medicine, 2020.
5. [IF = 6.832] Zhang Yamei et al."Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis." Stem Cell Re Ther. 2021 Dec;12(1):1-15
6. [IF = 4.534] Zixin Hou et al."microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis." Adipocyte. 2021;10(1):378-393

DEPOCYT (cytarabine) - Introduction

This product is made from D-arabinose or 5 '-cytosine nucleotides. Its hydrochloride is commonly used. It can inhibit DNA polymerase, interfere with nucleotide participation in DNA, inhibit nucleotide reductase, block cytosine nucleotide reduction to deoxycytosine nucleotide, but has no significant effect on RNA and protein synthesis. Ara-C the insertion of DNA, it inhibits DNA replication by forming a complex with topoisomerase I(topoisomerase I), resulting in DNA cleavage. RNA synthesis cannot be inhibited.
Last Update：2022-10-16 17:14:01
DEPOCYT (cytarabine)
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
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Product Name: Cytarabine Visit Supplier Webpage Request for quotation
CAS: 147-94-4
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Shanghai Yuanye Bio-Technology Co., Ltd.
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Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Cytarabine Request for quotation
CAS: 147-94-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple SpecificationsSpot supply
Product Name: Cytarabine Visit Supplier Webpage Request for quotation
CAS: 147-94-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: cytosine-1-beta-D-arabinofuranoside Request for quotation
CAS: 147-94-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Ara-C Visit Supplier Webpage Request for quotation
CAS: 147-94-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Cytarabine Request for quotation
CAS: 147-94-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
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DEPOCYT (cytarabine)
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