DIOC6(3)

DIOC6(3) - Names and Identifiers

Name	3,3-Dihexyloxacarbocyanine Iodide
Synonyms	NK 2280 DIOC6(3) 3,3-Dihexyloxacarbocyanine Iodide 3,3'-DIHEXYLOXACARBOCYANINE IODIDE 3,3'-Dihexyloxacarbocyanine iodide (DiOC6(3) iodide) 3-hexyl-2-[3-(3-hexyl-2(3h)-benzoxazolylidene)-1-propenyl]-benzoxazoliuiod 3-HEXYL-2-[3-(3-HEXYL-2(3H)BENZOXAZOLYLIDENE)-1-PROPENYL]BENZOXAZOLIUM IODIDE BENZOXAZOLIUM, 3-HEXYL-2-[3-(3-HEXYL-2(3H)-BENZOXAZOLYLIDENE)-1-PROPENYL]-, IODIDE 3-HEXYL-2-((E)-3-[3-HEXYL-1,3-BENZOXAZOL-2(3H)-YLIDENE]-1-PROPENYL)-1,3-BENZOXAZOL-3-IUM IODIDE
CAS	53213-82-4

DIOC6(3) - Physico-chemical Properties

Molecular Formula	C29H37IN2O2
Molar Mass	572.53
Density	1.2837 (estimate)
Melting Point	219-221 °C(lit.)
Solubility	Soluble in ethanol, methanol, dimethyl sulfoxide
Appearance	Powder
Color	Red
Maximum wavelength(λmax)	484 nm
BRN	9312562
Storage Condition	Room Temprature
Sensitive	Light Sensitive
Physical and Chemical Properties	Bioactive 3,3 '-Dihexyloxacarbocyanine iode is a carbonyl cyanine dye that can be used to detect changes in mitochondrial membrane potential.
In vitro study	Addition of cells to the cuvette containing 0.25 μM 3,3'-Dihexyloxacarbocyanine iodide (DiOCg(3)) leads to an increase in fluorescence, equilibration is rapid and is complete by 4 min. When f-met-leu-phe (10 -7 M) is added to neutrophils preequilibrated with 3,3'-Dihexyloxacarbocyanine iodide, there is a short lag period of 5 seconds. The lag period is followed by a rapid loss of fluorescence. Examination of 3,3'-Dihexyloxacarbocyanine iodide loaded neutrophils using fluorescence microscopy demonstrates that in resting neutrophils the brightest fluorescence is associated with long thin organelles which corresponds to the distribution of mitochondria.

DIOC6(3) - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	DM5285250
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	29269095

DIOC6(3) - Biological Applications

Detecting mitochondrial membrane potential,3,10–16,47,nucleic acid hybridization,prostate cancer,germination Bacillus anthracis spores; apoptosis assays; diagnostic assays; in photodynamic therapy; treating malaria,leishmaniasis,t

Last Update：2024-04-09 21:31:50