DL-α-羟基-β,β-二甲基-γ-丁内酯
DL-Pantolactone
CAS: 79-50-5
Molecular Formula: C6H10O3
DL-α-羟基-β,β-二甲基-γ-丁内酯 - Names and Identifiers
| Name | DL-Pantolactone |
| Synonyms | DL-LACTONE DL-Pantolactone DL-PANTOYL LACTONE DL-R-BUTYROLACTONE D-(-)-Pantoyl lactone 3-Amino-1-phenylurea hydrochloride (+-)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one Hydrazinecarboxamide, N-phenyl-, monohydrochloride 2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (+-)- DL-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMME-BUTYROLACTONE DL-alpha-Hydroxy-beta,beta-dimethyl-alpha-butyrolactone DL-Pantolactone, Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone, β,β-Dimethyl-α-hydroxy-γ-butyrolactone |
| CAS | 79-50-5 |
| EINECS | 201-210-7 |
| InChI | InChI=1/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3 |
| InChIKey | SERHXTVXHNVDKA-UHFFFAOYSA-N |
DL-α-羟基-β,β-二甲基-γ-丁内酯 - Physico-chemical Properties
| Molecular Formula | C6H10O3 |
| Molar Mass | 130.14 |
| Density | 1.165±0.06 g/cm3(Predicted) |
| Melting Point | 74-78 °C (lit.) |
| Boling Point | 121°C/11mmHg(lit.) |
| Flash Point | 122℃ |
| Solubility | H2O: soluble1g/10 mL, clear, colorless to almost colorless |
| Appearance | white needle |
| Color | Colourless Gel to White to Off-White |
| BRN | 80958 |
| pKa | 13.12±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Unstable in Aqueous Solution |
| MDL | MFCD00064333 |
| Physical and Chemical Properties | White or pale yellow crystals. Iron hydroxamate reaction was positive. |
| Use | Used as pharmaceutical intermediates and raw materials for cosmetics |
DL-α-羟基-β,β-二甲基-γ-丁内酯 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10-21 |
| HS Code | 29322090 |
DL-α-羟基-β,β-二甲基-γ-丁内酯 - Upstream Downstream Industry
| Raw Materials | Methyl alcohol Sodium cyanide Isobutyraldehyde |
DL-α-羟基-β,β-二甲基-γ-丁内酯 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| purpose | This product is an intermediate of pantothenic acid and is also used in other organic synthesis. used as raw materials for pharmaceutical intermediates and cosmetics |
| production method | After 2, 2-dimethyl-3-hydroxypropionaldehyde is prepared from isobutyraldehyde, it is added with sodium cyanide, after hydrolysis and acidification, internal esterification. 2, 2-dimethyl-3-hydroxypropionaldehyde was dissolved in water, and the mixture was put into a reaction pan, followed by adding an aqueous solution of sodium cyanide and an aqueous solution of calcium chloride. After homogenization, 50% sulfuric acid solution was added. Reaction to produce highly toxic hydrogen cyanide tail gas, with ferrous sulfate solution absorption. After reacting at 60-65 ° C. For 6h, the temperature was raised to 80-85 ° C. For 3H, the reaction was concentrated under reduced pressure, and 95% ethanol was added to precipitate inorganic salts. The filtrate was filtered, and ethanol was recovered under reduced pressure, followed by fractional distillation, and a fraction of 130-145 ° C. (1.33-2.44kPa) was collected to obtain DL-panyl lactone. |
Last Update：2024-04-09 20:52:54
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View History
DL-α-羟基-β,β-二甲基-γ-丁内酯
1-氯-2,5-二甲基-4-硝基苯
4-氨基-3-吡啶甲腈
4-氯-1-异丁基-1H-吡唑
7-Azabicyclo[2.2.1]heptane-1-methanol, ethanedioate (1:1)
2-氯-7-环戊基-7H-吡咯并[2,3-D]嘧啶-6-甲醛
17a-羟基-11b-羟基-3-氧代雄甾-1,4-二烯-17-甲酸氯甲酯
p-[(p-nitrophenyl)thio]toluene
2-氰基-5-降冰片烯
2-氯-3-溴-5-氨基吡啶
1-氯-2,5-二甲基-4-硝基苯
4-氨基-3-吡啶甲腈
4-氯-1-异丁基-1H-吡唑
7-Azabicyclo[2.2.1]heptane-1-methanol, ethanedioate (1:1)
2-氯-7-环戊基-7H-吡咯并[2,3-D]嘧啶-6-甲醛
17a-羟基-11b-羟基-3-氧代雄甾-1,4-二烯-17-甲酸氯甲酯
p-[(p-nitrophenyl)thio]toluene
2-氰基-5-降冰片烯
2-氯-3-溴-5-氨基吡啶
Raw Materials for DL-α-羟基-β,β-二甲基-γ-丁内酯