DL-METHIONINE METHYLSULFONIUM CHLORIDE
DL-METHIONINE METHYLSULFONIUM CHLORIDE
CAS: 1115-84-0
Molecular Formula: C6H14ClNO2S
DL-METHIONINE METHYLSULFONIUM CHLORIDE - Names and Identifiers
DL-METHIONINE METHYLSULFONIUM CHLORIDE - Physico-chemical Properties
| Molecular Formula | C6H14ClNO2S |
| Molar Mass | 199.7 |
| Melting Point | 134 ºC |
| Solubility | Water |
| Appearance | Off-White Solid |
| Storage Condition | 2-8℃ |
DL-METHIONINE METHYLSULFONIUM CHLORIDE - Effect of Methyl methanesulfonate on chromosome aberration of sperm in mice
Author:
Abstract:
using (C_(57) ×cba) F_1 mouse sperm and NIH mouse in vitro fertilization, the chromosome samples of fertilized eggs were prepared by culture, and the Methyl methanesulfonate (MMS) was observed. Effect on chromosome aberration of mouse sperm. MMS in vivo (25,50, 150 mg/kg), in vitro (75, μg/ml) after the treatment of sperm, sperm chromosome aberration rate increased significantly, dose-response relationship. The main type of distortion was staining type. This study shows that sperm DNA damage induced by MMS can be transmitted to spermatozoa and eggs; The model used is a reliable method to monitor the mutagenic effect of chemicals on germ cells (sperm, eggs).
Key words:
methyl methaphosphate in vitro fertilization sperm chromosome aberration
DOI:
CNKI:SUN:WSDL.0.1991-03-006
cited:
year:
1991
Last Update：2024-01-02 23:10:35
DL-METHIONINE METHYLSULFONIUM CHLORIDE - Effect of Methyl methanesulfonate on telomerase activity in CAOV3 cells
from VIP Journal Professional Edition
Author:
Liu Yongping , Zhao, Yang Ping , bright , Yao Yang , in country
Abstract:
objective: to investigate the relationship between telomerase activity and growth status of CAOV3 cells treated with Methyl methanesulfonate (MMS). Methods: trypan blue staining method to count live cells, thiazole Blue (MTT) method to determine the drug concentration, flow cytometry to observe cell apoptosis, telomeric repeat amplification assay (TRAP), telomerase activity was detected by polyacrylamide gel electrophoresis and silver staining. Results: there was no significant difference in the percentage of viable cells between the treated group and the untreated group. MMS mainly blocked CAOV3 cells in S phase, and no apoptotic peak was observed. Compared with the control group, the telomerase activity was increased in the treatment group. Conclusion: MMS can up-regulate telomerase activity in CAOV3 cells. The anti-apoptotic effect of CAOV3 cells on MMS may be related to the up-regulation of telomerase activity.
Key words:
telomerase Methyl methanesulfonate ovarian cancer cells apoptosis
DOI:
10.3969/j.issn.0258-4646.2003.02.004
year:
2003
Last Update：2023-08-16 22:05:47
DL-METHIONINE METHYLSULFONIUM CHLORIDE - A simple method for the preparation of methyl thiomethanesulfonate
from Palm Bridge research
Application (patent) number:
CN201911371655.9
application date:
2019-12-27
Public/Announcement Number:
CN111072539A
Public/announcement date:
2020.04.28
applicant (patent):
Beijing Technology and Business University
inventor:
Tian Hongyu , Liu Yongguo , Huang Shuai , Wang Hao , Liang Sen , Yang Shaoxiang , Sun Baoguo
National and provincial code:
CN110108
Abstract:
The present invention provides a simple preparation method of thiomethanesulfonic acid methyl ester of structure such as formula (I)
Last Update：2023-08-16 22:05:47
DL-METHIONINE METHYLSULFONIUM CHLORIDE - Validation of determination method for genotoxic impurity Methyl methanesulfonate
from titanium academic
Author:
Abstract:
through the development and verification of Methyl methanesulfonate method by gas chromatography, the feasibility and reliability of the analysis method are proved.
Key words:
genotoxic impurities Methyl methanesulfonate gas chromatograph headspace sampling
year:
2021
Last Update：2023-08-16 22:05:47
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DL-METHIONINE METHYLSULFONIUM CHLORIDE
4-(4-Fluorobenzoyl)piperidine hydrochloridde
2-Cyclopropylisonicotinonitrile
2,3,4,5,6-五甲基苯-1磺酰氯
2,4-D丁酯乳油
4-(4-Fluorobenzoyl)piperidine hydrochloridde
2-Cyclopropylisonicotinonitrile
2,3,4,5,6-五甲基苯-1磺酰氯
2,4-D丁酯乳油