DM4 top3
DM4
CAS: 796073-69-3
Molecular Formula: C38H54ClN3O10S
DM4 top3 - Names and Identifiers
| Name | DM4 |
| Synonyms | DM4 Ravtansine The element DM4 Mertansine Impurity 1 DM4 top3 Benzoicacid,5-(chlorosulfonyl)-4-methyl- N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)- N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) |
| CAS | 796073-69-3 |
DM4 top3 - Physico-chemical Properties
| Molecular Formula | C38H54ClN3O10S |
| Molar Mass | 780.37 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Melting Point | 185-187 °C (decomp) |
| Boling Point | 943.2±65.0 °C(Predicted) |
| Solubility | DMSO: 10 mM |
| pKa | 9.82±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death. |
DM4 top3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.281 ml | 6.407 ml | 12.814 ml |
| 5 mM | 0.256 ml | 1.281 ml | 2.563 ml |
| 10 mM | 0.128 ml | 0.641 ml | 1.281 ml |
| 5 mM | 0.026 ml | 0.128 ml | 0.256 ml |
Last Update：2024-01-02 23:10:35
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Product Name: DM4 Visit Supplier Webpage Request for quotationCAS: 796073-69-3
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Mobile: 18021002903
QQ: 3008007409
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