DNA Methyltransferase Inhibitor
RG108
CAS: 48208-26-0
Molecular Formula: C19H14N2O4
DNA Methyltransferase Inhibitor - Names and Identifiers
DNA Methyltransferase Inhibitor - Physico-chemical Properties
| Molecular Formula | C19H14N2O4 |
| Molar Mass | 334.33 |
| Density | 1.502±0.06 g/cm3(Predicted) |
| Melting Point | 192-194℃ |
| Boling Point | 606.0±50.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | powder |
| Color | yellow |
| pKa | 3.62±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Sensitive | Light Sensitive |
| Use | RG108 is a DNA methyltransferase inhibitor, IC50 is 115 nM, and does not cause covalent enzyme trapping. |
| In vitro study | RG108 potently blocks DNA methyltransferases in human cell lines in vitro and does not cause covalent enzyme entrapment. Incubation of cells with low micromolar concentrations of RG108 resulted in significant demethylation of genomic DNA without detectable toxicity. Interestingly, RG108 caused demethylation and reactivation of tumor suppressor genes, but it did not affect the methylation of centromeric gene sequences. In another study, synthesis and in vitro analysis of biotinylated RG108 conjugates were performed to assess interaction with DNA methyltransferases. Recent studies have shown that RG108 is able to significantly reduce DNA activity in SM-derived iPS cells compared to native SMs. |
DNA Methyltransferase Inhibitor - Risk and Safety
| WGK Germany | 3 |
DNA Methyltransferase Inhibitor - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.991 ml | 14.955 ml | 29.911 ml |
| 5 mM | 0.598 ml | 2.991 ml | 5.982 ml |
| 10 mM | 0.299 ml | 1.496 ml | 2.991 ml |
| 5 mM | 0.06 ml | 0.299 ml | 0.598 ml |
Last Update：2024-01-02 23:10:35
DNA Methyltransferase Inhibitor - Reference Information
| biological activity | RG108 is a DNA methyltransferase inhibitor with an IC50 of 115 nM, covalent enzyme trapping is not caused. RG108 (N-Phthalyl-L-tryptophan) is a DNA methyltransferase inhibitor with an IC50 of 115 nM in a cell-free assay that does not cause covalent enzyme trapping. |
| Target | Value |
| DNA methyltransferase (Cell-free assay) | 115 nM |
Last Update：2024-04-09 21:32:10
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Product Name: RG108 Visit Supplier Webpage Request for quotationCAS: 48208-26-0
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Spot supply
Product Name: RG108 Visit Supplier Webpage Request for quotationCAS: 48208-26-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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