DOCOSATETRAENOIC ACID
cis-7,10,13,16-Docosatetraenoic Acid
CAS: 28874-58-0
Molecular Formula: C22H36O2
DOCOSATETRAENOIC ACID - Names and Identifiers
DOCOSATETRAENOIC ACID - Physico-chemical Properties
| Molecular Formula | C22H36O2 |
| Molar Mass | 332.52 |
| Density | 0.9220 g/cm3 |
| Boling Point | 161-164.5 °C(Press: 0.07 Torr) |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Appearance | Oil |
| Color | Colourless |
| pKa | 4.76±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Light Sensitive |
| Physical and Chemical Properties | Bioactive adrenaline Acid (cis-7,10,13,16-Docosatetraenoic acid) is a natural polyunsaturated fatty Acid found mainly in the adrenal glands, brain, kidneys and vasculature. Adrenaline Acid regulates the vascular tone of the adrenal cortex. Adrenaline Acid is also an inflammation enhancer for non-alcoholic fatty liver disease. |
| Use | Introduction eicosatetraenoic acid is an unsaturated fatty acid which can be prepared from arachidonic acid in five steps. Such unsaturated fatty acids are generally derived from fish oils. |
DOCOSATETRAENOIC ACID - Risk and Safety
| WGK Germany | 3 |
DOCOSATETRAENOIC ACID - Uses and methods of synthesis
Target
Human Endogenous Metabolite
in vitro studies
Adrenic acid is produced via the elongation of arachidonic acid by ELOVL2 and 5. Interestingly, the hepatic level of free Adrenic Acid (22:4n6) is markedly higher in the CDAHFD-fed db/db mice than in the SD-fed db/db mice. In plasma, the difference in the adrenic acid level reaches statistical significance (p<0.001). It is also found that the concentrations of phospholipid species containing Adrenic Acid, such as PC or PE (40:4) (containing side chain 18:0/22:4), and LPC 22:4 (sn-1/sn-2), are also significantly increased. (sn-1/sn-2). The hepatic and plasma levels of Adrenic Acid, which is an omega 6 polyunsaturated fatty acid (PUFA), exhibit greater differences between the CDAHFD-fed db/db mice and the SD-fed db/db mice (8.6-fold higher vs. 1.6-fold higher in liver tissue, 5.3-fold higher vs. 2.2-fold higher in plasma) than those of well-known proinflammatory PUFA, such as Arachidonic Acid.
Last Update：2024-04-10 22:29:15
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QQ: 3008007409
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