Darunavir int
4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE
CAS: 169280-56-2
Molecular Formula: C20H29N3O3S
Darunavir int - Names and Identifiers
| Name | 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE |
| Synonyms | Darunavir int Darunavir intermediate 4-amino-N-(3-amino-2-hydroxy-4-phenylbutyl)benzenesulfonamide 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFOMIDE 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-ispobutylbenzenesulfonamide 4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzene-1-sulfonamide 4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE |
| CAS | 169280-56-2 |
| InChI | InChI=1/C20H29N3O3S/c1-15(2)13-23(27(25,26)18-10-8-17(21)9-11-18)14-20(24)19(22)12-16-6-4-3-5-7-16/h3-11,15,19-20,24H,12-14,21-22H2,1-2H3/t19-,20?/m0/s1 |
Darunavir int - Physico-chemical Properties
| Molecular Formula | C20H29N3O3S |
| Molar Mass | 391.53 |
| Density | 1.226±0.06 g/cm3(Predicted) |
| Melting Point | 136-139°C |
| Boling Point | 609.1±65.0 °C(Predicted) |
| Solubility | Chloroform (Slightly) DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Appearance | Solid |
| Color | White rto Off-White |
| pKa | 11.99±0.45(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.605 |
Darunavir int - Introduction
4-AMINO-N-[(2R,3S)-N-ISOBUTYLBENZENE-1-SULFONAMIDE (2,2 '-ammonium magnesium sulfonate), Acid Cap deoxyribonucleoside alcohol enzyme substrate, it is a chemical reagent.
[Nature]]
-Appearance: White crystal or crystalline powder
-Molecular formula: C18H35N5O5S
-Molecular weight: 457.57g/mol
-Melting point: 208-210 ° C
-Solubility: Soluble in water and acetonitrile, slightly soluble in methanol and ethanol
[Purpose]]
-As a substrate, it is often used for the analysis of enzyme activity and the determination of antioxidant properties.
-In biochemistry and molecular biology research, it is often used to determine the activity of antioxidants and enzymes.
-can also be used for hemoglobin to catalyze the generation of hydrogen peroxide.
[preparation method]]
At present, the more commonly used preparation methods are as follows:
1.4-hydroxy-2, 6-di-tert-butylbenzoic acid reacts with isobutylamine under the action of ether group and chlorophosphorous acid to obtain 4-isobutylbenzoic acid.
2. 4-isobutylbenzoic acid was treated with ozone in ammonia solution to obtain 4-isobutylbenzaldehyde.
3. 4-isobutylbenzaldehyde is converted to 4-amino-n-isobutylbenzaldehyde by amination reaction.
4.4.4-Amino-N-isobutyl benzaldehyde and 2R, 3s-diamino-2, 3-propanediol are reacted in a solvent such as benzene to obtain the target product.
[Safety Information]]
- ABTS is a chemical reagent and should be operated in a chemical laboratory.
-It is an organic compound that may cause irritation to the skin, eyes and respiratory tract. Wear safety glasses, gloves and protective clothing during operation.
-avoid contact with acid, oxidant and other substances, so as not to cause combustion or explosion.
-should be stored in a dry, well-ventilated place, and away from fire and flammable materials.
[Nature]]
-Appearance: White crystal or crystalline powder
-Molecular formula: C18H35N5O5S
-Molecular weight: 457.57g/mol
-Melting point: 208-210 ° C
-Solubility: Soluble in water and acetonitrile, slightly soluble in methanol and ethanol
[Purpose]]
-As a substrate, it is often used for the analysis of enzyme activity and the determination of antioxidant properties.
-In biochemistry and molecular biology research, it is often used to determine the activity of antioxidants and enzymes.
-can also be used for hemoglobin to catalyze the generation of hydrogen peroxide.
[preparation method]]
At present, the more commonly used preparation methods are as follows:
1.4-hydroxy-2, 6-di-tert-butylbenzoic acid reacts with isobutylamine under the action of ether group and chlorophosphorous acid to obtain 4-isobutylbenzoic acid.
2. 4-isobutylbenzoic acid was treated with ozone in ammonia solution to obtain 4-isobutylbenzaldehyde.
3. 4-isobutylbenzaldehyde is converted to 4-amino-n-isobutylbenzaldehyde by amination reaction.
4.4.4-Amino-N-isobutyl benzaldehyde and 2R, 3s-diamino-2, 3-propanediol are reacted in a solvent such as benzene to obtain the target product.
[Safety Information]]
- ABTS is a chemical reagent and should be operated in a chemical laboratory.
-It is an organic compound that may cause irritation to the skin, eyes and respiratory tract. Wear safety glasses, gloves and protective clothing during operation.
-avoid contact with acid, oxidant and other substances, so as not to cause combustion or explosion.
-should be stored in a dry, well-ventilated place, and away from fire and flammable materials.
Last Update：2024-04-10 22:29:15
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