Deferasirox Intermediate

Deferasirox Intermediate - Names and Identifiers

Name	2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Synonyms	Deferasirox Intermediate Deferasirox Benzoxazin IMpurity 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one 2-(2-Hydroxyphenyl)benz[e][1,3]oxazin-4-one 2-(o-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE 4H-1,3-Benzoxazin-4-one, 2-(2-hydroxyphenyl)- 4H-1,3-benzoxazin-4-one, 2-(2-hydroxyphenyl)- 2-(2-Hydroxy-phenyl)-benzo[e][1,3]oxazin-4-one 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one
CAS	1218-69-5
EINECS	1592732-453-0
InChI	InChI=1/C14H9NO3/c16-11-7-3-1-5-9(11)14-15-13(17)10-6-2-4-8-12(10)18-14/h1-8,16H

Deferasirox Intermediate - Physico-chemical Properties

Molecular Formula	C14H9NO3
Molar Mass	239.23
Density	1.34±0.1 g/cm3(Predicted)
Melting Point	204.0 to 208.0 °C
Boling Point	425.0±47.0 °C(Predicted)
Flash Point	210.803°C
Solubility	Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Very Slightly, Heated)
Vapor Presure	0mmHg at 25°C
Appearance	Yellow solid
Color	Pale Yellow to Light Yellow
Maximum wavelength(λmax)	['371nm(H2O)(lit.)']
pKa	8.07±0.35(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.657

Deferasirox Intermediate - Introduction

2-(2-Hydroxyphenyl)-4H-benzo [E][1,3] oxazin-4-one, often referred to as EBQ, is an organic compound with the following properties and uses:

Nature:
1. Appearance: EBQ is white crystalline powder or crystal.
2. chemical formula: C18H13NO2.
3. melting point: about 200 ℃.
4. Solubility: Soluble in some organic solvents, such as ethanol, methanol and chloroform.

Use:
1. EBQ, as a fluorescent compound, can be used as a fluorescent probe in biochemistry and molecular biology experiments.
2. Because EBQ has the function of stimulating fluorescence, it can also be used in the study of drug delivery.
3. EBQ can also be used as an intermediate in organic synthesis.

Preparation Method:
EBQ is prepared by various methods. A common method is to obtain it by oxidizing and aminating 1,3-diaminobenzene, keto acid and o-phenol in the presence of benzyl alcohol.

Safety Information:
1. EBQ is an organic matter and generally has certain toxicity. Attention should be paid to avoid contact with skin and inhalation of dust.
2. in the use or storage process, should avoid contact with strong acid and alkali substances.
3. When using EBQ for experiments, laboratory safety regulations should be observed and operated under well-ventilated conditions. In case of any discomfort or accident, seek medical help immediately.

Last Update：2024-04-09 15:17:51