Name | Tephrosin |
Synonyms | Tephrosin Deguelinol I Isotephrosin Hydroxydeguelin Tephrosin (synthetic) |
CAS | 76-80-2 |
Molecular Formula | C23H22O7 |
Molar Mass | 410.42 |
Density | 1.2284 (rough estimate) |
Melting Point | 198° (218-220°) |
Boling Point | 450.42°C (rough estimate) |
pKa | 10.47±0.40(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.5300 (estimate) |
Use | Fish toxin |
In vitro study | Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) . |
Hazard Symbols | N - Dangerous for the environment |
Risk Codes | 50 - Very Toxic to aquatic organisms |
Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
biological activity | tephroxin is a kind of natural carotenoid with strong anti-tumor activity. Tephrosin induces degradation of EGFR and ErbB2 by inducing receptor internalization. |