Di-tert-butyl morpholine-3,4-dicarboxylate

Di-tert-butyl morpholine-3,4-dicarboxylate - Names and Identifiers

Name	N-BOC-3-hydroxymethylmorpholine
Synonyms	3-Hydroxymethyl-4-Bocmorpholine N-BOC-3-hydroxymethylmorpholine 4-BOC-3-HYDROXYMETHYL-MORPHOLINE N-Boc-3-hydroxymethyl-morpholine 1-N-BOC-2-HYDROXYMETHYL MORPHOLINE Di-tert-butyl morpholine-3,4-dicarboxylate tert-Butyl-3-(hydroxymethyl)morpholin-4-carboxylat tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 3-Hydroxymethyl-Morpholine-4-Carboxylic Acid Tert-Butyl Ester 4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester 4-morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
CAS	473923-56-7
InChI	InChI=1/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-7-8(11)6-12/h8,12H,4-7H2,1-3H3

Di-tert-butyl morpholine-3,4-dicarboxylate - Physico-chemical Properties

Molecular Formula	C10H19NO4
Molar Mass	217.26
Density	1.118±0.06 g/cm3(Predicted)
Boling Point	320.7±27.0 °C(Predicted)
Flash Point	147.8°C
Vapor Presure	2.53E-05mmHg at 25°C
pKa	14.85±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.474

Di-tert-butyl morpholine-3,4-dicarboxylate - Introduction

N-BOC-3-hydroxymethylmorpholine(N-BOC-3-hydroxymethylmorpholine) is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White solid
-Molecular formula: C12H21NO4
-Molecular weight: 247.3g/mol
-Melting point: 70-72 degrees Celsius
-Boiling point: 338.5 degrees Celsius (expected)
-Solubility: Soluble in some organic solvents such as dichloromethane and ethanol

Use:
- N-BOC-3-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester is a compound with functional groups, commonly used in organic synthesis as a temporary protective agent for protecting groups (protecting hydroxyl or amine groups).
-It is often used in the synthesis of some biologically active compounds in drug synthesis.

Preparation Method:
N-BOC-3-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester can be prepared by the following steps:
-Step 1: N-BOC morpholine and formaldehyde are reacted to generate 3-hydroxymethylmorpholine.
-Step 2: The product obtained in step 1 is reacted with tert-butanol and dimethyl sulfoxide, and an excess of triformamidine is added at low temperature to obtain tert-butyl N-BOC-3-hydroxymethylmorpholine-4-carboxylate.

Safety Information:
- N-BOC-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester should be stored in a dry, cool place.
-During operation, care should be taken to avoid inhaling the dust, vapor or smoke of the compound.
-Wear suitable personal protective equipment such as chemical protective gloves, eye protection and chemical protective face mask when using.
-Follow all relevant safety procedures during storage and handling.

Last Update：2024-04-09 19:05:49