Diethyl 2-acetamido-2-(2-((di(-chloroethyl)amino)methyl)-5-nitrobenzyl)malonate
Diethyl(acetylamino)((2-((bis(2-chloroethyl)amino)methyl)-5-nitrophenyl)methyl)propanedioate
CAS: 74980-13-5
Molecular Formula:
Diethyl 2-acetamido-2-(2-((di(-chloroethyl)amino)methyl)-5-nitrobenzyl)malonate - Names and Identifiers
Diethyl 2-acetamido-2-(2-((di(-chloroethyl)amino)methyl)-5-nitrobenzyl)malonate - Physico-chemical Properties
| Physical and Chemical Properties | Crystalline compound. Melting point 106-110 ℃. |
Diethyl 2-acetamido-2-(2-((di(-chloroethyl)amino)methyl)-5-nitrobenzyl)malonate - References
| uses | intermediates for eliminating tumor mustard. |
| Production method | p-nitrotoluene can be chloromethylated with dichloromethyl ether to generate 2-chloromethyl-4-nitrotoluene, and then It is condensed with diethyl acetaminomalonate to obtain (acetamido) (2-methyl-5-nitrobenzyl) diethyl malonate, then brominate (methyl on the benzene ring) to obtain (acetamido) (2-bromomethyl-5-nitrobenzyl) diethyl malonate, and finally condensed and chlorinated with ethanolamine to obtain the product. |
Last Update：2024-04-09 21:11:58
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