Diethyl ethoxymethylenemalonate
Diethyl ethoxymethylenemalonate
CAS: 87-13-8
Molecular Formula: C10H16O5
Diethyl ethoxymethylenemalonate - Names and Identifiers
| Name | Diethyl ethoxymethylenemalonate |
| Synonyms | EMME AKOS BBS-00004230 LABOTEST-BB LT02094814 ETHYL ETHOXYMETHYLENE MALONATE Diethyl ethoxymethylenemalonate 1,1-DICARBETHOXY-2-ETHOXYETHYLENE 2,2-DICARBETHOXYVINYL ETHYL ETHER ETHYL A-CARBETHOXY-B-ETHOXYACRYLATE diethyl 2-(ethoxymethylene)malonate Ethoxymethylenmalonic acid diethylester Propylene glycol ethoxymethylenemalonate diethyl (ethoxymethylidene)propanedioate ETHYL 3-ETHOXY-2-(ETHOXYCARBONYL)ACRYLATE Propanedioic acid,(ethoxymethylene)-, diethyl ester |
| CAS | 87-13-8 |
| EINECS | 201-725-7 |
| InChI | InChI=1/C10H16O5/c1-4-13-7-8(9(11)14-5-2)10(12)15-6-3/h7H,4-6H2,1-3H3 |
| InChIKey | LTMHNWPUDSTBKD-UHFFFAOYSA-N |
Diethyl ethoxymethylenemalonate - Physico-chemical Properties
| Molecular Formula | C10H16O5 |
| Molar Mass | 216.23 |
| Density | 1.080g/mLat 20°C(lit.) |
| Melting Point | -33°C |
| Boling Point | 279-283°C(lit.) |
| Flash Point | 311°F |
| Water Solubility | insoluble |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | <0.1 hPa |
| Appearance | Liquid |
| Color | Clear colorless to light yellow |
| BRN | 880058 |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.463 |
| Physical and Chemical Properties | Liquid. |
| Use | An important organic raw material with a variety of active groups in the molecule, which can be condensed and condensed with a variety of substances. Now it is mainly used for the synthesis of norfloxacin; Used as an intermediate of medicine and pesticide |
Diethyl ethoxymethylenemalonate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | OO1100000 |
| TSCA | Yes |
| HS Code | 29189090 |
| Toxicity | LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg |
Diethyl ethoxymethylenemalonate - Upstream Downstream Industry
| Raw Materials | Ethyl malonate Triethyl Orthoformate |
Diethyl ethoxymethylenemalonate - Nature
Open Data Verified Data
liquid. The relative density was 1. 07. Boiling point 279~281 deg C. Refractive index 4620. Flash point 155 °c.
Last Update：2024-01-02 23:10:35
Diethyl ethoxymethylenemalonate - Preparation Method
Open Data Verified Data
The starting material diethyl malonate and triethyl orthoformate are condensed in the presence of a catalyst to obtain diethyl ethoxymethylene malonate. The product was refined by fractional distillation.
Last Update：2022-01-01 10:33:46
Diethyl ethoxymethylenemalonate - Use
Open Data Verified Data
organic synthetic raw materials, used in medicine, dyes and other products manufacturing.
Last Update：2022-01-01 10:33:46
Diethyl ethoxymethylenemalonate - Reference Information
| LogP | 1.5-2.1 at pH7 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| synthesis method | the synthesis of diethyl ethoxymethylidenemalonate usually adopts the condensation reaction of diethyl malonate and triethyl orthoformate and the removal of a part of ethanol to obtain the condensation intermediate, the condensation intermediate in turn eliminates one molecule of ethanol to give diethyl ethoxymethylidene malonate. |
| Use | An important organic raw material containing a variety of active groups in the molecule, with a variety of substances for condensation and cyclization condensation, is now mainly used for the synthesis of norfloxacin organic synthesis of raw materials for pharmaceuticals, dyes and other products manufacturing. It is an important drug intermediate, widely used in medicine; Pesticides and additives and other aspects of the synthesis, is the production of chloroquine; Norfloxacin; intermediates of lomefloxacin |
| production method | the mixture of triethyl orthoformate, acetic anhydride, diethyl malonate and anhydrous zinc oxide was stirred and heated at 102-115 ℃ for 2.5h, heat preservation at 115-127 ℃ for 7H, then add partial acetic anhydride and triethyl orthoformate, and continue to heat up to 127-145 ℃ for 2H, 145-155 ℃ for 2H. The reaction was then cooled to room temperature and filtered. The filtrate was distilled under reduced pressure, and the fraction of 108-110 ° C. (33Pa) was collected to obtain a finished product with a yield of 50-60%. |
| autoignition temperature | 215°C |
Last Update：2024-04-10 22:29:15
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Raw Materials for Diethyl ethoxymethylenemalonate