Doxepine hydrochloride
doxepin HCL
CAS: 1229-29-4
Molecular Formula: C19H22ClNO
Doxepine hydrochloride - Names and Identifiers
Doxepine hydrochloride - Physico-chemical Properties
| Molecular Formula | C19H22ClNO |
| Molar Mass | 315.84 |
| Melting Point | 187-189°C |
| Boling Point | 413.3°C at 760 mmHg |
| Flash Point | 9℃ |
| Water Solubility | Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO. |
| Solubility | 1 M HCl: 50mg/mL |
| Vapor Presure | 4.87E-07mmHg at 25°C |
| Appearance | White to off-white powder |
| Color | white to off-white |
| Maximum wavelength(λmax) | ['298nm(lit.)'] |
| Merck | 14,3435 |
| Storage Condition | 2-8°C |
| Stability | Store in Freezer at -20°C |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Doxepin inhibits the reuptake of serotonin and norepinephrine. It has negligible reuptake of dopamine. Doxepin has an antagonistic effect on various receptors, including H1,H2,5-HT1,5-HT2, α1-adrenergic, and mACh. |
Doxepine hydrochloride - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | HQ4375000 |
| HS Code | 29329990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 147mg/kg |
Doxepine hydrochloride - Reference
| Reference Show more | 1. [IF=5.909] Xi He et al."One-pot synthesis of C-doping and defects co-modified g-C3N4 for enhanced visible-light photocatalytic degradation of bisphenol A."J Environ Chem Eng. 2021 Dec;:106911 |
Doxepine hydrochloride - Standard
Authoritative Data Verified Data
This product is a cis-trans isomer mixture of N, n-dimethyl-3-dibenzo [6,e] oxaphene-11 (6h) subunit-1-propylamine hydrochloride. The content of C19H21NO. HC1 shall be between 98.0% and 102.0% based on the dry product.
Last Update：2024-01-02 23:10:35
Doxepine hydrochloride - Trait
Authoritative Data Verified Data
- This product is white powder, easy to wet, wet color gradient to yellowish.
- This product is soluble in water and soluble in ethanol or dichloromethane.
melting point
The melting point of this product (General rule 0612 first method) is 185~191°C.
Last Update：2022-01-01 15:03:56
Doxepine hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- take this product, add O.Olmol/L hydrochloric acid in methanol solution dissolved and diluted into a solution containing 0401 mg per 1 ml, according to UV-visible spectrophotometry (General Principles) determination, there is a maximum absorption at a wavelength of 297nm, and the absorbance is 0.50 to 0.55.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 347).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:03:56
Doxepine hydrochloride - Exam
Authoritative Data Verified Data
acidity
take 0.10g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.5~6.5.
Related substances
take this product, add mobile phase to dissolve and dilute to make each lml containing l. 0 mg of the solution, as the test solution; Take 2ml of precision, put in a 100ml measuring flask, dilute to the scale with mobile phase, shake, Take 5ml of precision, put in a 50ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the chromatographic conditions under the content determination item, 20ul of the control solution and the test solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the sum of the two main peaks of doxepin in the control solution (0.2% ) , the sum of each impurity peak area shall not be greater than 2.5 times (0.5%) of the sum of the two main peak areas of doxepin in the control solution.
isomer ratio
According to the determination method under the content determination item, the cis isomer (Z) contained in the sample shall be 17.0% ~ 23.0% calculated by the peak area according to the external standard method.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 15:03:57
Doxepine hydrochloride - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with octylsilane as filler; 0.1% mol/L sodium dihydrogen phosphate solution-methanol (65:35) containing 0.2 triethylamine (adjusted to pH 2.5 with 2mol/L phosphoric acid) mobile phase; Detection wavelength was 254nm; Column temperature was 50°C. The theoretical plate number is not less than 1500 based on the cis isomer (Z), and the resolution of the trans isomer (E) and the cis isomer (Z) peaks should meet the requirements.
assay
take this product, precision weighing, plus mobile phase dissolution and dilution made in each lml containing about 0. The solution of lmg was accurately measured and 20m1 was injected into the human liquid chromatograph, and the chromatogram was recorded. The reference substance of doxepin hydrochloride was taken and determined by the same method. According to the external standard method to doxepin two peak area and calculation, that is obtained.
Last Update：2022-01-01 15:03:58
Doxepine hydrochloride - Category
Authoritative Data Verified Data
antidepressants.
Last Update：2022-01-01 15:03:58
Doxepine hydrochloride - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:03:58
Doxepine hydrochloride - Doxepin Hydrochloride Tablets
Authoritative Data Verified Data
This product contains doxepin hydrochloride calculated as doxepin (C19H21NO), which should be 90.0% ~ 110.0% of the labeled amount.
trait
This product is sugar-coated tablet or film-coated tablet, white to yellowish after removing the coating.
identification
- take this product fine powder, add O.Olmol/L hydrochloric acid in methanol solution dissolved and diluted into a solution containing about 0401 mg per 1 ml, filtered, take the filtrate according to UV-visible spectrophotometry (general) determination, there is an absorption maximum at a wavelength of 297nm.
- in the chromatogram recorded under the content determination item, the retention time of the two main peaks of the cis and trans isomers of the test solution should be consistent with the retention time of the two main peaks of the control solution.
- take an appropriate amount of fine powder of this product, add water to grind, filter, take the filtrate drop plus silver nitrate test solution, and show a white curd-like precipitate.
examination
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 45 minutes, 10ml of the solution was filtered, and the filtrate was used as the test solution; The appropriate amount of doxepin hydrochloride was accurately weighed, water was added for dissolution and quantitative dilution to prepare a solution containing 30ug per 1 ml as a control solution. The test solution and the reference solution were taken, and the absorbance at the wavelength of 0401 NM was measured by ultraviolet-visible spectrophotometry (general rule), and the dissolution amount of each tablet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, remove the coating, precision weighing, fine grinding, precision weighing an appropriate amount (about 50mg equivalent to doxepin), put it in a 100ml measuring flask, add appropriate amount of mobile phase and ultrasound to dissolve doxepin hydrochloride and dilute to the scale, shake well, filter, take 10ml of continuous filtrate accurately, put it in 50ml measuring flask, add mobile phase to dissolve and dilute to the scale, as a test solution. The results were obtained by multiplying the results by 0.8846 as determined under determination of doxepin hydrochloride.
category
Same as doxepin hydrochloride.
specification
25mg (based on C19H21NO)
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:03:59
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CAS: 1229-29-4
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CAS: 1229-29-4
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Email: sales@tnjchem.com
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