Doxycycline Hyclate USP
Doxycycline Hyclate
CAS: 24390-14-5
Molecular Formula: C24H31ClN2O9
Doxycycline Hyclate USP - Names and Identifiers
Doxycycline Hyclate USP - Physico-chemical Properties
| Molecular Formula | C24H31ClN2O9 |
| Molar Mass | 526.97 |
| Melting Point | 206-209?C (dec.) |
| Boling Point | 685.2°C at 760 mmHg |
| Specific Rotation(α) | D25 -110° (c = 1 in 0.01N methanolic HCl) |
| Flash Point | 368.2°C |
| Water Solubility | Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether. |
| Solubility | DMSO:88 mg/mL (198.0 mM) |
| Vapor Presure | 1.03E-19mmHg at 25°C |
| Appearance | Yellow powder |
| Color | yellow to greenish-yellow |
| Merck | 14,3440 |
| BRN | 5702728 |
| Storage Condition | 2-8°C |
| MDL | MFCD00800994 |
| In vitro study | Compared with the control group, Doxycycline hyclate 10% (DOXY) was significantly toxic to osteoblasts, with an average cell activity of 84%, and caused alkaline phosphatase activity in osteoblasts (about 56%). Significantly higher than the control group. Doxycycline hyclate 10% (DOXY) may slightly alter the morphology of osteoblasts. |
| In vivo study | Doxycycline hyclate is able to effectively treat acute E. canis infection in puppies. Doxycycline hyclate (5 mg/kg, P. O.) reduces collagenase activity in rabbit corneas. In a rabbit alkali burn model, Doxycycline hyclate (5 mg/kg, P. O.) promotes corneal epidermal cell regeneration in rabbits, a result likely to be that the drug inhibits excessive collagenase activity. In contrast to Doxycycline hyclate, which prevented 43% of orally treated mice, sustained-release doxycycline hyclate completely protected mice from infection and pathology caused by infection. Doxycycline hyclate has a bioavailability of 70%, a Cmin of 1 mg/L, a Cmax of 2.3 mg/L, and a half-life of 7 hours in calves with immature rumen function. |
Doxycycline Hyclate USP - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | QI8925000 |
| HS Code | 29413000 |
| Toxicity | LD50 i.p. in rats: 262 mg/kg (Goldenthal) |
Doxycycline Hyclate USP - Reference
| Reference Show more | 1. Zhang Xianglin, Dong Furen, Lei Zhen, Wang Gang, Zheng Shilei. Effects of doxycycline and lipiodol embolization on metastasis, MMP-2 and MMP-9 expression of rabbit VX2 liver implant tumor [J]. Jiangsu Medicine, 2011,37(17):1997-1999. 2. Zheng Shilei, Zhang Xianglin, Dong Furen, Lei Zhen, Wang Gang, Li Guoce, Xu Na. Effects of doxycycline and lipiodol embolization on VEGF and MMP-2 expression in rabbit VX2 liver implant tumor [J]. World Journal of Chinese Digestion, 2010,18(31):3338-3342. 3. Liu Minfang, Cao Mengrui, Li Rongxu, et al. Isolation, Identification and Drug Sensitivity Analysis of Waterfowl-derived Salmonella in Some Areas of Guangdong [J]. Heilongjiang Animal Husbandry and Veterinary Medicine, 2018(10). 4. Tang, Rui, et al. "Fabrication of carboxymethyl cellulose and chitosan modified Magnetic alkaline Ca-bentonite for the adsorption of hazardous doxycycline." Colloids and Surfaces A: Physicochemical and Engineering Aspects 610 (2021): 125730.https://doi.org 5. [IF = 3.041] Ye Qin et al. "MMP-2/9-oriented combinations enhance antitumor efficacy of EGFR/HER2-targeting fusion proteins and gemcitabine." Oncorep. 2014 Jul;32(1):121-130 6. [IF = 2.896] Bao-Shan He et al. "Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification." Anal Methods-Uk. 2018 Feb;10(7):783 7. [IF = 7.514] Shu Han et al. "Preparation of mesh covalent organic extraction framework tetracycline Tppa-2-based adsorption magnetic molecularly imprinted composite for selective of residues from animal-derived foods." Food Chem. 2022 Aug;384:132601 8. [IF = 5.882] Zi-Jian Zheng et al. "MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria." Virulence. 2022;13(1):77-88 |
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