ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE
ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE
CAS: 1009306-52-8
Molecular Formula: C14H15Cl2NO2
ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE - Names and Identifiers
| Name | ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE |
| Synonyms | ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE |
| CAS | 1009306-52-8 |
ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C14H15Cl2NO2 |
| Molar Mass | 300.19 |
| Melting Point | 144 °C(Solv: isopropanol (67-63-0)) |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | IRRITANT |
| MDL | MFCD07308466 |
ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29334900 |
ETHYL 2-(CHLOROMETHYL)-4-METHYLQUINOLINE-3-CARBOXYLATE HYDROCHLORIDE - Introduction
ETHYL 2-(CHLOROMETHYL)-is a compound with the following properties:
-Appearance: Colorless or slightly yellow solid powder.
-Solubility: Soluble in water and organic solvents, such as methanol and ethanol.
Some of the main uses of this compound include:
-Chemical synthesis: As an intermediate in organic synthesis, it can be used to synthesize other organic compounds.
-Drug research: It has anti-biological activity and can be used for drug research and development.
The preparation method of the compound is as follows:
1.2-chloromethylquinoline -4-carboxylic acid ethyl ester is reacted with formaldehyde to obtain 2-hydroxymethylquinoline -4-carboxylic acid ethyl ester.
2. Treat ethyl 2-hydroxymethylquinoline -4-carboxylate with thionyl chloride and trimethylamine to generate ethyl 4-methyl -2-chloromethylquinoline -3-carboxylate.
3. Finally, 4-methyl -2-chloromethylquinoline -3-carboxylic acid ETHYL ester is reacted with hydrochloric acid to obtain ETHYL 2-(CHLOROMETHYL)-hydroxychloride.
When using and handling this compound, you need to pay attention to the following safety information:
-This compound is irritating and should be avoided by inhalation, ingestion or contact with skin and eyes.
-Wear appropriate protective gloves and eye protection when in use.
-It should be used in a well-ventilated place to avoid prolonged contact.
-If inhalation or contact occurs, wash the affected area immediately and seek medical help if necessary.
-Appearance: Colorless or slightly yellow solid powder.
-Solubility: Soluble in water and organic solvents, such as methanol and ethanol.
Some of the main uses of this compound include:
-Chemical synthesis: As an intermediate in organic synthesis, it can be used to synthesize other organic compounds.
-Drug research: It has anti-biological activity and can be used for drug research and development.
The preparation method of the compound is as follows:
1.2-chloromethylquinoline -4-carboxylic acid ethyl ester is reacted with formaldehyde to obtain 2-hydroxymethylquinoline -4-carboxylic acid ethyl ester.
2. Treat ethyl 2-hydroxymethylquinoline -4-carboxylate with thionyl chloride and trimethylamine to generate ethyl 4-methyl -2-chloromethylquinoline -3-carboxylate.
3. Finally, 4-methyl -2-chloromethylquinoline -3-carboxylic acid ETHYL ester is reacted with hydrochloric acid to obtain ETHYL 2-(CHLOROMETHYL)-hydroxychloride.
When using and handling this compound, you need to pay attention to the following safety information:
-This compound is irritating and should be avoided by inhalation, ingestion or contact with skin and eyes.
-Wear appropriate protective gloves and eye protection when in use.
-It should be used in a well-ventilated place to avoid prolonged contact.
-If inhalation or contact occurs, wash the affected area immediately and seek medical help if necessary.
Last Update：2024-04-09 21:21:28
