Egtazic acid
Egtazic acid
CAS: 67-42-5
Molecular Formula: C14H24N2O10
Egtazic acid - Names and Identifiers
| Name | Egtazic acid |
| Synonyms | ebonta Egtazic acid 1,2-bis(2-dicarboxymethylaminoethoxy)ethane ethylenedioxybis(ethyleneamino)tetraaceticacid 3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETIC ACID Ethylene glycol-bis-(2-aminoethyl)tetraacetic acid 12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-9-dioxa-3 9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-6 ETHYLENE GLYCOL BIS-(BETA-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC 6,9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid 3,12-bis(carboxylatomethyl)-6,9-dioxa-3,12-diazoniatetradecane-1,14-dioate |
| CAS | 67-42-5 |
| EINECS | 200-651-2 |
| InChI | InChI=1/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)/p-2 |
Egtazic acid - Physico-chemical Properties
| Molecular Formula | C14H24N2O10 |
| Molar Mass | 380.35 |
| Density | 1.2838 (rough estimate) |
| Melting Point | 241°C (dec.)(lit.) |
| Boling Point | 507.99°C (rough estimate) |
| Flash Point | 363.9°C |
| Water Solubility | slightly soluble |
| Solubility | Soluble in 1M NaOH (100 mM), Slightly soluble in water. |
| Vapor Presure | 3.76E-20mmHg at 25°C |
| Appearance | White-like powder |
| Color | White |
| Merck | 14,3529 |
| BRN | 1717370 |
| pKa | 1.47±0.10(Predicted) |
| Storage Condition | room temp |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4590 (estimate) |
| MDL | MFCD00004291 |
| In vitro study | EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC 50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules. |
Egtazic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | AH3760000 |
| TSCA | Yes |
| HS Code | 29225000 |
| Toxicity | LD50 orally in Rabbit: 3587 mg/kg |
Egtazic acid - Reference
| Reference Show more | 1. Fu, ya, Zhou, Chunxia, Zhu, panhong, et al. Effects of pH on solubility and molecular conformation of tilapia myosin under three different ionic strengths [J]. Food and Fermentation Industries 2017 043(009):64-70. 2. Feng Ruihong, Pengzhi, Yang Ping, et al. Effect of CaCl2 on water holding capacity and microstructure of low-salt tilapia myosin gel. Food and machinery. 3. Li Ting, Zhu, Pan Hong, Qi Hui, Hong Zhou, Chunxia, Hong Pengzhi. Thermal denaturation and aggregation of tilapia myosin under different ionic strength [J]. Food and Fermentation Industry 2018 44(01):86-91. 4. Zhou Chunxia, Feng Rui, Li Ting, Yang Ping, Hong Pengzhi. Inhibition of thermal aggregation of tilapia myosin by SDS under low salt conditions and its mechanism [J]. Journal of Guangdong Ocean University, 2020, 40(04):82-89. 5. Zhou Chunxia, Shi Jiaojiao, Fu Junya, etc. Effects of lysine and arginine on solubility and conformation of tilapia myosin under three ionic strengths [J]. Modern food science and technology, 2016, 032(012):99-104. 6. Gao Jing, Wang Nan, Guan Sijing, etc. Study on the signal mechanism of stomatal closure induced by Beauveria bassiana [J]. Shaanxi Agricultural Sciences, 2019, 065(005):72-75. 7. Jiang, Wenxin, et al. "Effect of mild ozone oxidation on structural changes of silver carp (Hypophthalmichthys molitrix) myosin." Food and Bioprocess Technology 10.2 (2017): 370-378.https://doi.org/10.1007/s11947-016-1828-5 8. Jiang, Wenxin, et al. "Effect of mild ozone oxidation on structural changes of silver carp (Hypophthalmichthys molitrix) myosin." Food and Bioprocess Technology 10.2 (2017): 370-378.https://doi.org/10.1007/s11947-016-1828-5 9. [IF=4.465] Jiang Wenxin et al."Effect of Mild Ozone Oxidation on Structural Changes of Silver Carp (Hypophthalmichthys molitrix) Myosin."Food Bioprocess Tech. 2017 Feb;10(2):370-378 10. [IF=4.534] Chuanxin Zhang et al."Neohesperidin promotes the osteogenic differentiation of human bone marrow stromal cells by inhibiting the histone modifications of lncRNA SNHG1."Cell Cycle. 2021;20(19):1953-1966 11. [IF=3.216] Shuai Yuan et al."Neohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR."Drug Des Dev Ther. 2020; 14: 5419-5430 |
Egtazic acid - Introduction
EGTA is the most widely used calcium ion selective chelating agent for the determination of calcium in the presence of magnesium. The complex formed by it with calcium ions is 100,000 times more stable than the complex formed with magnesium ions, and is used to prepare calcium buffer and control the concentration of calcium ions. Complexing agent and masking agent for measuring trace metals in volumetric analysis and photometric analysis. Barium, strontium, copper, magnesium and zinc can also be titrated. Deoxysequencing buffer component of RNA in RNA reverse transcriptase Deoxysequencing buffer component of RNA in RNA reverse transcriptase
Last Update：2022-10-16 17:27:50
Egtazic acid - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | EGTA is a special calcium chelator. EGTA has a Kd of 7.4 nM at physiological pH (60.5), and has a high specificity for Ca2 than Mg2. EGTA significantly inhibited the substrate adhesion capacity of inflammatory macrophages. |
| Use | is a calcium chelating agent, the effect of potassium salt is relatively better. |
Last Update：2024-04-09 15:16:52
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