Escin monosodium salt
Escin monosodium salt
CAS: 20977-05-3
Molecular Formula: C53H82O36S4
Escin monosodium salt - Names and Identifiers
| Name | Escin monosodium salt |
| Synonyms | Sodium escinate Entsufon SodiuM Sodium Aescinate Escin sodium salt Escin monosodium salt Escin, Mononatriumsalz Escin, monosodium salt Aescin monosodium salt Sodium Aescinate for Injection Aescin polysulphate sodium salt |
| CAS | 20977-05-3 |
| EINECS | 244-133-4 |
| InChI | InChI=1/C54H84O23.Na/c1-22(23(2)71-24(3)57)45(68)70-21-54-26-16-49(4,5)43(42(54)65)73-32(54)17-53(9)25(26)10-11-30-50(6)14-13-31(51(7,20-56)29(50)12-15-52(30,53)8)74-48-40(76-46-36(62)33(59)27(58)19-69-46)38(64)39(41(77-48)44(66)67)75-47-37(63)35(61)34(60)28(18-55)72-47;/h10,22-23,26-43,46-48,55-56,58-65H,11-21H2,1-9H3,(H,66,67);/q;+1/t22?,23?,26?,27-,28-,29?,30?,31?,32-,33+,34-,35+,36-,37-,38+,39+,40-,41+,42?,43-,46+,47-,48-,50?,51-,52?,53-,54?;/m1./s1 |
Escin monosodium salt - Physico-chemical Properties
| Molecular Formula | C53H82O36S4 |
| Molar Mass | 1124.22 |
| Melting Point | 250-252 °C |
| Solubility | Soluble in water and methanol, soluble in ethanol and butanol, insoluble in chloroform and acetic acid. |
| Appearance | White powder |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| Physical and Chemical Properties | Sodium salt of a saponin derived from an extract of dried, ripe fruits (seeds of Acanthaceae). |
Escin monosodium salt - Reference
| Reference Show more | 1. Gao Jing, Ding Nan, Chen Danyang, et al. Study on Ethanol Extraction Technology of Aescin from Saluo Zi [J]. Research and Practice of Modern Chinese Medicine, 2018, v.32;No.161(02):38-40. |
Escin monosodium salt - Reference Information
| Plant extract | Sodium aescinate (aescinate, trade name: Mattona) is a triterpene saponin sodium salt proposed in the dry and mature fruits of the traditional Chinese medicine Brahma. Foreign countries are extracted from the ripe fruits of the crude drug horse chestnut (horse chestnut). Studies have shown that it can resist infection, anti-exudation, and reduce swelling; enhance blood vessel wall tension and contraction, improve microcirculation; anti-tumor, protect the liver; anti-oxidation, scavenging free radicals; promote gastrointestinal peristalsis, inhibit gastric acid secretion; have neuroprotective effect on ischemic brain tissue; hypoglycemic effect. Clinically, it is mainly used to treat acute facial neuritis, headache, acute myelitis, neck, shoulder, waist and leg pain, hypertensive cerebral hemorrhage, acute cerebral infarction, central serous chorioretinopathy, early postoperative inflammatory intestinal obstruction, pressure ulcer. |
| source plant | dry mature fruit (Brahma) of the Achestnut (Aesulus wilsonii). Figure 1 is a Brahma |
| Pharmacological effects | 1, anti-infection, anti-exudation, and detumescence: the site of action is the blood vessel wall, and the permeability of the blood vessel wall increases during the inflammatory reaction. Sodium aescinate can change the permeability of inflammatory capillaries, promote edema reabsorption, prevent neutrophils from entering the microcirculation, and keep vascular endothelial cells in a state of non-adhesion to neutrophils, prevent neutrophil adhesion, activation, exudation and secondary venous wall damage, and prevent the development of local inflammation. Studies have proved that aescin can eliminate the swelling of rat claws induced by ovalbumin and dextran in the early stage of inflammation. Oral administration of aescin can reduce the capillary permeability of rats induced by histamine and serotonin, and reduce the permeability of rabbit capillaries induced by chloroform. The results of the experimental study on anti-hemorrhage cerebral edema showed that the observation under light microscope in the treatment group found that the hemorrhage and cell edema were significantly reduced after treatment, the ultrastructure of mitochondria and endoplasmic reticulum tended to be complete, and the biochemical test found that the concentration of Na decreased significantly. The concentration of K was significantly increased, which indicated that sodium aescinate had a significant therapeutic effect on cerebral edema after experimental cerebral hemorrhage. 2. Enhance blood vessel wall tension and contractility, and improve microcirculation: It can promote the selective release of prostaglandin F- 2 α in veins, increase venous tension, promote lymphatic reflux, improve capillary blood stasis, and improve microcirculation. The application of sodium aescinate can significantly enhance the venous pressure, flow rate and thoracic lymphatic flow rate of dogs. 3. Anti-tumor and liver protection: It can inhibit the proliferation of human chronic bone marrow cell-like leukemia k562 cells. In the treatment of liver cancer in mice, the tumor volume gradually decreases with the increase of the dose. It can reduce the increase of alanine aminotransferase caused by liver injury in mice caused by carbon tetrachloride, and has obvious protective effect on experimental liver injury in mice. 4. Antioxidant scavenging free radicals: It can significantly reduce the energy consumption of tissue cells and maintain the function of vascular endothelial cells. At the same time, sodium aescinate reduces the exudation of neutrophils by activating endothelial cells and increasing the adhesion to neutrophils, which effectively reduces the production of reactive oxygen species. Moreover, sodium aescinate can reduce the consumption of superoxide dismutase, more effectively scavenge oxygen free radicals, improve the damage caused by bleeding, and accelerate tissue repair. 5. Promote gastrointestinal peristalsis and inhibit gastric acid secretion: Use it to significantly inhibit the increase in gastric acid secretion caused by gastrin and histamine, and can participate in gastric acid regulation through both nerve and endocrine pathways. 6. Neuroprotective effect on ischemic brain tissue: Experimental rats blocked the left middle cerebral artery reperfusion, and immediately injected sodium aescinate intraperitoneally. The cerebral infarction area of rats in the treatment group was significantly smaller than that of rats in the control group, and the number of apoptosis was significantly less than that of the control group. It has a protective effect on transient and focal cerebral ischemia in rats. 7. Hypoglycemic effect: Sodium aescinate can reduce the absorption of glucose when it exists in the jejunum, and achieve the purpose of lowering blood sugar by inhibiting the absorption of glucose in the digestive tract. It can prevent and treat diabetes caused by elevated blood sugar after meals. effect. |
| clinical application | (1) acute facial neuritis: compared with prednisone in the treatment of idiopathic acute facial neuritis, there was no significant difference in cure rate and improvement rate between the two groups (all P>0.05), but sodium aescinate avoided the adverse reactions of corticosteroids. (2) Headache: Sodium aescinate combined with acetylglutamine is effective in the treatment of angioneurotic headache and premenstrual tension headache, and mannitol combined with traumatic subarachnoid hemorrhage. (3) acute myelitis: the application of vitamin B, dibazole, acupuncture and other plus sodium aescinate in the treatment of acute myelitis, the cure rate and improvement rate were significantly higher than the application of corticosteroids. (4) neck, shoulder, waist and leg pain: the cure rate and improvement rate of the treatment of lumbar disc herniation were significantly higher than those of the application of Yaotongning chlorzoxazone; the total effective rate of sodium aescinate combined with mannitol in the treatment of cervical spondylotic radiculopathy was significantly higher than that of dexamethasone mannitol. (5) Hypertensive cerebral hemorrhage and acute cerebral infarction: Sodium aescinate can significantly reduce intracranial pressure, accelerate the absorption rate of cerebral edema and hematoma, contribute to the recovery of neurological function, and promote the secretion of adrenal cortisol. Play hormone-like anti-infection, anti-exudation, and reduce swelling. (6) central serous chorioretinopathy: sodium aescinate can improve the absorption of macular protein deposits and pigmentation, improve vision after treatment, and have a low recurrence rate. (7) early postoperative inflammatory intestinal obstruction: it can promote the recanalization of intestinal obstruction and reduce the pain of patients with long-term catheterization, which is related to the role of sodium aescinate in reducing intestinal wall edema and intestinal inflammatory exudation and promoting intestinal peristalsis. (8) Pressure ulcers: Its treatment of pressure ulcers can soften induration, reduce exudation, and relieve pain. Compared with previous treatment methods, it has a faster onset and a shorter course of treatment. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: used for brain edema, swelling caused by trauma or surgery, and also for venous reflux disorders. sodium aescinate is an anti-inflammatory drug for swelling. It has the effects of anti-exudation, increasing venous tension and swelling, anti-inflammatory and improving blood circulation. |
Last Update：2024-04-09 15:16:48
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