Ethacridine Lactate,Rivanol,Acrinol
Ethacridine lactate monohydrate
CAS: 6402-23-9
Molecular Formula: C18H21N3O4
Ethacridine Lactate,Rivanol,Acrinol - Names and Identifiers
| Name | Ethacridine lactate monohydrate |
| Synonyms | RIVANOL ETHODIN ETHODIN MONOHYDRATE Ethacridine lactate monohydrate ETHACRIDINE LACTATE MONOHYDRATE Ethacridine Lactate,Rivanol,Acrinol |
| CAS | 6402-23-9 |
| EINECS | 642-272-9 |
| InChI | InChI=1/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)/p+1 |
Ethacridine Lactate,Rivanol,Acrinol - Physico-chemical Properties
| Molecular Formula | C18H21N3O4 |
| Molar Mass | 343.38 |
| Melting Point | 243-245°C(lit.) |
| Boling Point | 523.5°C at 760 mmHg |
| Flash Point | 270.4°C |
| Solubility | Sparingly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| Vapor Presure | 4.72E-11mmHg at 25°C |
| Appearance | Powder |
| Color | Yellow |
| Merck | 14,3716 |
| BRN | 3642805 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| MDL | MFCD00149646 |
| Physical and Chemical Properties | Rivanol is a bright yellow crystalline powder, odorless, bitter, slightly soluble in water, soluble in hot water, the aqueous solution is yellow, the light observation, visible green fluorescence, and the aqueous solution is unstable, light discoloration, insoluble in ethanol. Should be placed in brown glass bottles, sealed, stored in a cool place. The structural formula is shown in the figure below: The Overview, physical and chemical properties, main uses and usage, adverse reactions and precautions of rivanol are compiled by Shi Yan. (2015-11-17) |
| Use | Disinfection antiseptic for Disinfection of wounds and mucous membranes, separation of precipitates during preparation of plasma proteins |
Ethacridine Lactate,Rivanol,Acrinol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | OD4725000 |
| HS Code | 29339980 |
| Toxicity | LD50 s.c. in mice: 0.12 g/kg (Rubbo) |
Ethacridine Lactate,Rivanol,Acrinol - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.912 ml | 14.561 ml | 29.122 ml |
| 5 mM | 0.582 ml | 2.912 ml | 5.824 ml |
| 10 mM | 0.291 ml | 1.456 ml | 2.912 ml |
| 5 mM | 0.058 ml | 0.291 ml | 0.582 ml |
Last Update：2024-01-02 23:10:35
Ethacridine Lactate,Rivanol,Acrinol - Reference Information
| Overview | rivanol is a lactate-hydrate of alpha-ethoxy-6, 9-diaminoacridine, it is a bactericidal preservative for external use, which has a strong killing effect on Gram-positive bacteria and a few gram-negative bacteria, and has a good antibacterial effect on cocci, especially streptococcus, and has a strong activity in alkaline environment. This product is irritant, the treatment concentration of general tissue without damage, but can stimulate the uterine smooth muscle contraction, softening, relaxation of the cervix, so it can be used for the induction of labor in women with no obvious side effects. |
| Main use and usage | 1. Various wounds, skin and mucous membrane exudation, erosion and infection of the wound: 0.1% ~ 0.3% solution to wash or wet compress infected wounds; Or 0.1%, 0.5% ointment for external application of the wound. 2. Induction of labor in the second trimester of pregnancy: use this product to prepare 0.2% of the injection (can be diluted by Sterile Water for Injection) through the lower abdominal wall for intra-amniotic injection, more than 20 weeks of pregnancy each 10 ml, under 20 weeks of pregnancy, 5 ml each time. A dose of up to 50~100 mg, but the maximum amount of 120 mg. The output is about 42 hours after General Administration. If the output is not obtained for more than 48 hours, the second injection or other method may be used, the 0.1% solution was injected into the uterine cavity with a catheter, and the catheter was retained for 24 hours and then removed. |
| adverse reactions | Generally, the commonly used concentration has no damage to tissues, and long-term use may delay wound healing. A small number of patients with skin irritation response, should be discontinued. |
| note | 1. Aqueous solution in the preservation process, especially under exposure, can be decomposed to produce highly toxic products, if the naked eye observation of the solution is Brown green, it is confirmed that the decomposition. 2. This product is easy to precipitate and precipitate when mixed with alkali or iodine solution. 3. Long-term use of this product may delay wound healing. |
| Use | Disinfection antiseptic for Disinfection of wounds and mucous membranes, separation of precipitates in the preparation of plasma protein Disinfection preservation for Disinfection of the wound and mucosa, separation of precipitates in the preparation of plasma protein |
Last Update：2024-04-09 20:52:54
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