Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate
Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate
CAS: 53554-29-3
Molecular Formula: C8H10N2O3S
Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate - Names and Identifiers
Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate - Physico-chemical Properties
| Molecular Formula | C8H10N2O3S |
| Molar Mass | 214.24 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 136-144°C |
| Boling Point | 340.4°C at 760 mmHg |
| Flash Point | 159.7°C |
| Vapor Presure | 4.37E-05mmHg at 25°C |
| Appearance | Solid |
| pKa | 6.48±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.601 |
| MDL | MFCD00023234 |
Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate - Reference Information
| Introduction | 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinoformate is an organic intermediate, which can be obtained from methyl thiourea sulfate and diethyl ethoxymethylene malonate as raw materials. 1, 4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinoate ethyl ester is a key intermediate in the preparation of Avanafil. |
| preparation | methyl thiourea sulfate (75.2g,0.4mol) was added to a solution with a mass fraction of 16% NaOH(250mL,1.18mol) and stirred for 30min, then diethyl ethoxymethylene malonate (103.4g,0.48mol) was dissolved in 160mL of ethanol and slowly dropped into the reaction solution, after dropping, react at room temperature for 10h. When a large amount of white solid is precipitated, white solid (84.7g,99.7%) is obtained by suction filtration, water washing and vacuum drying. ESE-MS(m/z):249[M H], 236.9[M Na], compared with the literature, it can be known as 1, ethyl 4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinoformate. |
| application | 1, 4-dihydro-2-methylmercapto-4-oxo-5-pyrimidine ethyl acetate can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes. |
Last Update：2024-04-09 02:00:09
Supplier List
Spot supply
Product Name: Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate Request for quotationCAS: 53554-29-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate Request for quotation
CAS: 53554-29-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 53554-29-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Avanafil Impurity 26 Visit Supplier Webpage Request for quotationCAS: 53554-29-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate Visit Supplier Webpage Request for quotation
CAS: 53554-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 53554-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate Request for quotationCAS: 53554-29-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate Request for quotation
CAS: 53554-29-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 53554-29-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Avanafil Impurity 26 Visit Supplier Webpage Request for quotationCAS: 53554-29-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate Visit Supplier Webpage Request for quotation
CAS: 53554-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 53554-29-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History