Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate

Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate - Names and Identifiers

Name	7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER
Synonyms	3-Carbethoxy-4-hydroxy-7-chloroquinoline Ethyl7-chloro-4-hydroxy-3-quinolinecarboxylate Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate ethyl 7-chloro-4-oxo-1H-quinoline-3-carboxylate Ethyl-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 4-Hydroxy-7-chloroquinoline-3-carboxylic acid ethyl ester 7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER 3-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-, ethyl ester
CAS	16600-22-9

Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate - Physico-chemical Properties

Molecular Formula	C12H10ClNO3
Molar Mass	251.67
Density	1.386
Melting Point	296-298℃
Boling Point	366.8±37.0 °C(Predicted)
pKa	2.18±0.50(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Physical and Chemical Properties	Chemical properties crystalline compounds. Melting point 297 ℃.
Use	Use chloroquine intermediate.

Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate - Production method

It can be heated and condensed with m-chloroaniline and triethyl orthoformate to form bis (m-chlorophenyl) formamidine, and then condensed with diethyl malonate with the participation of boron trifluoride to obtain (m-chlorophenylamino) diethyl methylene malonate, which is heated and cyclified in paraffin oil to obtain the product.

Last Update：2024-04-10 22:29:15