Ethyl 6-aminopyridine-2-carboxylate

Ethyl 6-aminopyridine-2-carboxylate - Names and Identifiers

Name	Ethyl 6-aminopyridine-2-carboxylate
Synonyms	ethyl 6-aminopicolinate 2-Amino-6-carbethoxypyridine 6-Aminopicolinic Acid Ethyl Ester ETHYL 6-AMINOPYRIDINE-2-CARBOXYLATE Ethyl 6-aminopyridine-2-carboxylate 6-Amino-2-pyridinecarboxylic acid ethyl ester 6-Aminopyridine-2-carboxylic acid ethyl ester 2-Pyridinecarboxylic acid, 6-amino-, ethyl ester 2-pyridinecarboxylic acid, 6-amino-, ethyl ester 2-Pyridinecarboxylicacid,6-amino-,ethylester(9CI)
CAS	69142-64-9
InChI	InChI=1/C8H10N2O2/c1-2-12-8(11)6-4-3-5-7(9)10-6/h3-5H,2H2,1H3,(H2,9,10)

Ethyl 6-aminopyridine-2-carboxylate - Physico-chemical Properties

Molecular Formula	C8H10N2O2
Molar Mass	166.18
Density	1.192
Melting Point	56-58℃
Boling Point	330℃
Flash Point	153℃
Solubility	soluble in Methanol
Vapor Presure	0mmHg at 25°C
Appearance	powder to crystal
Color	White to Yellow to Green
Maximum wavelength(λmax)	['337nm(MeOH)(lit.)']
pKa	1.87±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.559

Ethyl 6-aminopyridine-2-carboxylate - Introduction

Ethyl 6-aminopyridine-2-carboxylate is an organic compound with the chemical formula C9H11N3O2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Ethyl 6-aminopyridine-2-carboxylate is a white to light yellow crystal or crystalline powder.
-Solubility: It is insoluble in water, but soluble in organic solvents (such as ethanol, chloroform, dimethylformamide, etc.).
-Melting point: Its melting point is about 130-134 degrees Celsius.

Use:
- Ethyl 6-aminopyridine-2-carboxylate is widely used in the synthesis of biologically active organic molecules in the field of medicinal chemistry.
-It is an intermediate for the preparation of a variety of drugs and biologically active compounds, especially for the synthesis of pyridine drugs.

Preparation Method:
- Ethyl 6-aminopyridine-2-carboxylate can be synthesized by the following steps:
1. Ethyl 2-chloroacetate and 6-aminopyridine were esterified in the presence of sodium carbonate.
2. After the esterification reaction is completed, carry out crystallization purification to obtain Ethyl 6-aminopyridine-2-carboxylate product.

Safety Information:
- Ethyl 6-aminopyridine-2-carboxylate's chemical safety instructions should be followed, including proper use and storage methods.
-It is an organic compound with certain toxicity and direct contact with skin and eyes should be avoided.
-Use appropriate personal protective equipment such as lab gloves, safety glasses, etc.
-If swallowed or inhaled, seek medical attention immediately.

Last Update：2024-04-09 02:00:47