Name | Actein |
Synonyms | ACTEIN Actein Actein (20 mg) Furostanol Saponins FENUGREEK EXTRACT POWDER 9,19-CYCLOLANOSTANE-BETA-D-XYLOPYRANOSIDE |
CAS | 18642-44-9 |
Molecular Formula | C37H56O11 |
Molar Mass | 676.83 |
Density | 1.36 |
Melting Point | 246-250°C |
Specific Rotation(α) | -75.7 |
Appearance | Brown powder |
pKa | 12.14±0.70(Predicted) |
Storage Condition | 2-8℃ |
HS Code | 2938900000 |
Reference Show more | 1. Liu, L., Xiang, Y., Wang, Z. et al. Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction. NPG Asia Mater 11, 81 (2019). https://doi.org/10.1038/s41427-019-0185-z 2. Zhou, W., Wang, X., Sun, X., Hu, J., Zhang, R., & Hong, Z. (2017). Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway. International Journal of Oncology, 51, 1831-1841. https://doi.org/10.3892/ijo.2017.4150 3. [IF=3.571] Wen-Di Zhou et al."Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway."Int J Oncol. 2017 Dec;51(6):1831-1841 |
biological activity | Actein is a triterpene glycoside isolated from the rhizome of Cimicifuga foetida. Actein inhibits cell proliferation, induces autophagy and apoptosis by promoting ROS/JNK activation and inactivating the AKT pathway in human bladder cancer. Actein has little toxicity in vivo. |