Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
CAS: 268731-07-3
Molecular Formula: C27H22N2O4
Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid - Names and Identifiers
| Name | Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid |
| Synonyms | FMOC-D-TPI FMOC-D-TPI-OH Fmoc-D-Tpi-OH FMOC-D-THNH(3)-OH FMOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-TRYPTOLINE-3-CARBOXYLIC ACID (R)-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, N2-FMOC protected FMOC-D-1,2,3,4-TETRAHYDRO-9H-PYRIDO-[3,4-B]-INDOLE-3-CARBOXYLIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID (3R)-2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid |
| CAS | 268731-07-3 |
| InChI | InChI=1/C27H22N2O4/c30-26(31)25-13-21-20-11-5-6-12-23(20)28-24(21)14-29(25)27(32)33-15-22-18-9-3-1-7-16(18)17-8-2-4-10-19(17)22/h1-12,22,25,28H,13-15H2,(H,30,31)/t25-/m1/s1 |
Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C27H22N2O4 |
| Molar Mass | 438.47 |
| Density | 1.396±0.06 g/cm3(Predicted) |
| Boling Point | 702.4±60.0 °C(Predicted) |
| Flash Point | 378.6°C |
| Vapor Presure | 1.04E-20mmHg at 25°C |
| pKa | 3.92±0.20(Predicted) |
| Storage Condition | Store at -15°C |
| Refractive Index | 1.713 |
Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
Fmoc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid - Introduction
Fmoc-D-1,2,3, acid is a chemical compound, its chemical formula is C34H29NO4, molecular weight is 511.60. It is an amino acid derivative containing a Fmoc protecting group and has the structure of tetrahydro-beta-carboline and formic acid. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: White or off-white crystalline solid
-Melting point: about 165-170 ° C
-Insoluble in water, soluble in organic solvents such as dichloromethane and dimethyl sulfoxide
Use:
Fmoc-D-1,2,3, acid is widely used in the field of organic synthesis, often used in the synthesis of peptide compounds or drugs, as part of amino acid residues.
Method:
Fmoc-D-1,2,3, acid can be synthesized by the following steps:
1. D-1,2,3, 4-tetrahydro-β-carboline-3-carboxylic acid was reacted with chloromethyl dimethyl-n-butyl ammonium salt to generate 1,2,3, 4-Tetrahydro-β-carboline-3-carboxylic acid
2.1,2, 3,4-tetrahydro-β-carboline-3-carboxylic acid reacts with Fmoc-Cl to produce N-Fmoc-D-1,2,3, 4-Tetrahydro-β-carboline-3-carboxylic acid
Safety Information:
Fmoc-D-1,2,3, acid is a chemical, and you need to pay attention to safe operation when using it. It may cause irritation to the eyes, skin and respiratory tract, so you should wear appropriate protective measures, such as laboratory coats, protective glasses and gloves. In addition, it should be operated in a well-ventilated area to avoid inhaling the vapors of the substance. If skin contact or inhalation occurs, rinse immediately with water and seek medical help.
Nature:
-Appearance: White or off-white crystalline solid
-Melting point: about 165-170 ° C
-Insoluble in water, soluble in organic solvents such as dichloromethane and dimethyl sulfoxide
Use:
Fmoc-D-1,2,3, acid is widely used in the field of organic synthesis, often used in the synthesis of peptide compounds or drugs, as part of amino acid residues.
Method:
Fmoc-D-1,2,3, acid can be synthesized by the following steps:
1. D-1,2,3, 4-tetrahydro-β-carboline-3-carboxylic acid was reacted with chloromethyl dimethyl-n-butyl ammonium salt to generate 1,2,3, 4-Tetrahydro-β-carboline-3-carboxylic acid
2.1,2, 3,4-tetrahydro-β-carboline-3-carboxylic acid reacts with Fmoc-Cl to produce N-Fmoc-D-1,2,3, 4-Tetrahydro-β-carboline-3-carboxylic acid
Safety Information:
Fmoc-D-1,2,3, acid is a chemical, and you need to pay attention to safe operation when using it. It may cause irritation to the eyes, skin and respiratory tract, so you should wear appropriate protective measures, such as laboratory coats, protective glasses and gloves. In addition, it should be operated in a well-ventilated area to avoid inhaling the vapors of the substance. If skin contact or inhalation occurs, rinse immediately with water and seek medical help.
Last Update：2024-04-09 20:49:11
