Fosthiazate 30
Fosthiazate
CAS: 98886-44-3
Molecular Formula: C9H18NO3PS2
Fosthiazate 30 - Names and Identifiers
Fosthiazate 30 - Physico-chemical Properties
| Molecular Formula | C9H18NO3PS2 |
| Molar Mass | 283.35 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | <25 °C |
| Boling Point | bp0.5 198° |
| Flash Point | 178.3°C |
| Vapor Presure | 1.04E-05mmHg at 25°C |
| Appearance | neat |
| pKa | -2?+-.0.20(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | n19.6D 1.5334 |
| Physical and Chemical Properties | The appearance of the pure product is light yellow liquid. B.p. 198 ℃/66.66Pa, vapor pressure 5.6 × 10-4Pa (25 ℃), solubility in water 9.85g/L (0.87%), partition coefficient 1.75. |
Fosthiazate 30 - Risk and Safety
| Risk Codes | R21 - Harmful in contact with skin R23/25 - Toxic by inhalation and if swallowed. R39 - Danger of very serious irreversible effects R41 - Risk of serious damage to eyes R43 - May cause sensitization by skin contact R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S25 - Avoid contact with eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2810 |
| WGK Germany | 3 |
| RTECS | TB1707000 |
| HS Code | 29341000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 104, 91, 73, 57 orally; in male, female rats (mg/kg): 2396, 861 dermally. LC50 in male, female rats (mg/l): 0.832, 0.558 by inhalation (Toki). |
Fosthiazate 30 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| organophosphate nematicide | , the main mode of action is to inhibit the synthesis of root knot nematode acetylcholinesterase, which has strong contact activity and is also highly active against some pests that have been resistant to traditional insecticides. Thiazole phosphorus is mainly used to control nematodes, aphids, etc., is one of the few nematicidal products, suitable for the production of pollution-free vegetables. It has good control effect on root-knot nematodes, root-rot nematodes, stem nematodes, cyst nematodes and other nematodes, and has good plant conduction effect, it can prevent invasion and has a killing effect on invaded nematodes and the like. Annual crops are effective for 2~3 months, perennial crops are effective for 4~6 months, and the dosage is 1.5~2kg/mu. In Shandong Vegetable area, it is generally used twice per season, 4~6 kilograms each time, the use of crop costs 200 yuan per season. In China has been registered on the cucumber, tomato, watermelon, can be widely used in vegetables, bananas, fruit trees, herbs and other crops. Can use crops: carrot, eggplant, radish, yam, potato, garlic, sweet potato, watermelon, banana and tobacco.|
| toxicity | Acute Oral LD5057 ~ 73mg/kg in rats and 91~104mg/kg in mice; rats with acute percutaneous LD502396mg/kg (male), 861 mg/kg (female); Rats with acute inhalation of LD500.832 mg/L (male), 0.558mg/L (female). Hen Delayed Neurotoxicity was negative. It is irritating to rabbit eyes and non-irritating to skin. Carp LD50208mg/L (48h), Daphnia 2.17mg/L. |
| uses | insecticides and nematicides, the main mode of action is to inhibit the acetylcholinesterase of target pests, affects the ecology of the second larval stage. It is used to control many pests of veratoptera, Lepidoptera, Coleoptera and Diptera in the ground, and it is also very effective for underground root pests; It is also effective for many mites, and has good killing activity against various nematodes, it has a good absorption-killing activity against the commonly used insecticides against pests (e. G., aphids). It is most effective to mix thiazolium in soil immediately after application, and it can be applied directly to the soil surface before crop planting, and can also be used in crop sowing. The recommended dosage is 1~4kg/hm2. derivatives of thiadiazole; Pharmaceutical intermediates |
| production method | preparation of thiazolidine 2-oxide 488mg β-mercaptoethylamine was synthesized from β-mercaptoethylamine, 3.86g (Ph2PO)2O or [(PhO)2PO]2O and triethylamine are dissolved in acetonitrile, and CO2 is added for 1 day at 50~60 ℃, 2-oxothiazolidine was obtained. CO (80ml/min) was introduced into a mixed solution of 0.02mL β-mercaptoethylamine, 0.05mol triethylamine, 0.05mol Se and acetonitrile, and reacted at room temperature to obtain 2-oxothiazolidine with a yield of 96%. From a solution of 2-oxoxazolidine in methanol at 70 °c, the resulting mixture was reacted at 90 °c for 8H to give 2-oxothiazolidine in 85% yield. Preparation of S-SEC-butyl-O-ethylthiophosphoryl chloride, examples of preparation of EtO (PrS)P (O) Cl are reported in the literature: 0.13mol of PCl3 with 0.2mol of (EtO)3p was reacted at 55 °c for 2H to give a mixture of EtOPCl2 and (EtO)2PCl. To the mixture was added 35.5% PhMe solution containing 0.325molr PrSCl at -20 °c, 65g of a mixture containing EtO (PrS)P (O) Cl 72.2% was obtained, in addition PrSP(O)Cl2 23.7%, (EtO)2(PrS)PO 3.2% and Pr2s20. 9%, further separation of EtO(PrS)P(O)Cl. The literature indicates that S-SEC-butyl-O-ethylthiophosphoryl chloride can be prepared from PCl3 by a method similar to that described above. Synthesis of thiazole thiophos n-butyl lithium method 1.5g of 2-oxothiazolidine was dissolved in 30ml of tetrahydrofuran, cooled, and then n-hexane solution (1.65mol) of n-butyl lithium was added dropwise, and the mixture was stirred for 15min, then, 10ml of tetrahydrofuran solution containing 5g of S-SEC-butyl-O-ethylthiophosphoryl chloride was added dropwise thereto, the mixture was stirred for another 30min, reacted at room temperature for 3 days, and poured into water after reaction, then extracted with ethyl acetate, washed with water, dried and dissolved to obtain 2~3g of the desired product, the yield was 70% ~ 90%. Sodium metal method toluene and sodium metal were added to the reactor and the temperature was raised to reflux temperature under nitrogen. After the metal sodium was dissolved, the mixture was stirred and dispersed, and a solution of 2-oxothiazolidine in tetrabene was added dropwise, and the reaction was continued for 2H. After cooling to 15 °c, S-SEC-butyl-O-ethylthiophosphoryl chloride was added dropwise and reacted for 1H. After post-treatment, thiazole thiophos was obtained with a purity of 96.4% and a recovery rate of 91.2% based on phosphorus oxychloride. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:49:45
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