GR 38032F
ONDANSETRON
CAS: 99614-02-5;116002-70-1
Molecular Formula: C18H19N3O
GR 38032F - Names and Identifiers
GR 38032F - Physico-chemical Properties
| Molecular Formula | C18H19N3O |
| Molar Mass | 293.36 |
| Density | 1.1385 (rough estimate) |
| Melting Point | 231-232° |
| Boling Point | 435.21°C (rough estimate) |
| Solubility | Soluble in DMSO (10 mg/mL, warm), water (partly miscible), and DMF. |
| Appearance | solid |
| Color | white |
| pKa | pKa 7.4 (Uncertain) |
| Storage Condition | −20°C |
| Refractive Index | 1.5855 (estimate) |
| Physical and Chemical Properties | Crystallization from methanol, melting point 231-232 °c. Ondansetron Hydrochloride Dihydrate: C18 H19N3O? HCl? 2H2O. [99614-01-4]. A white crystalline solid was obtained from water-isopropanol, melting point 178.5-179.5 °c. Ondansetron Hydrochloride Monohydrate: C18H19N3O? HCl? H2O. Crystallization, melting point 186~187 deg C. 3S-form:[α]D25-14 °(C = 0.19, methanol). 3R-form:[α]D24 16 °(C = 0.34, methanol). |
| Use | A serotonin 5-HT3 receptor antagonist. |
GR 38032F - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | FE6375500 |
| HS Code | 29339900 |
| Toxicity | TDLo vn-man: 229 mg/kg/I LANCAO 344,190,94 |
GR 38032F - Nature
Open Data Verified Data
crystallized from methanol, melting point 231-232 °c.
Last Update：2024-01-02 23:10:35
GR 38032F - Preparation Method
Open Data Verified Data
2-bromoaniline reacts with 1,3-cyclohexanedione, and then dehydrobromides to form tetrahydrocarbazole derivative, which reacts with dimethylamine and paraformaldehyde and then with methyl iodide, finally, the reaction was stirred with 2-methyl -1 H-triazole in dimethylformamide to obtain ondansetron. Alternatively, the reaction between cyclohexanone and phenylhydrazine yields tetrahydrocarbazole. It is dissolved in tetrahydrofuran and water, in ammonia drop add 2,3,5.6 a tetrachloro 1,4 a benzoquinone tetrahydrofuran solution, stirred to oxidation products. The product was refluxed with ethanol, concentrated hydrochloric acid, paraformaldehyde and dimethylamine hydrochloride. After the treatment, concentrated hydrochloric acid was added and stirred in acetone, and the obtained ammonia methylation product was reacted with 2-methylimisazole, followed by methyl iodide and potassium carbonate, and stirred at room temperature until the solid disappeared. Ondansetron was obtained by treatment. It was dissolved in a mixture of acetone and water, and concentrated hydrochloric acid was added for reaction to obtain ondansetron hydrochloride dihydrate. Can also be from 1,2,3,9-four oxygen -4H-carbazole -4-one with dimethylamine and diformaldehyde reaction, and then reaction with methyl iodide, finally, the reaction with 2-methyl-lH-imazole in dimethylformamide yields ondansetron.
Last Update：2022-01-01 09:23:22
GR 38032F - Introduction
Ondansetron is a serotonin 5-HT3 receptor antagonist, mainly used for antiemetic.
Last Update：2022-10-16 17:30:33
GR 38032F - Use
Open Data Verified Data
The United Kingdom Glaxo company development, 1990 in France, the United Kingdom market. The product is a highly selective serotonin (5-HT3) receptor antagonist, can inhibit Nausea caused by chemotherapy and radiotherapy Vomit, with high strength and high selectivity, can control the small intestine and CTZ receptors caused by the stimulation of Vomit. It is suitable for the treatment of Nausea Vomit caused by chemotherapy and radiotherapy, and can also be used for the prevention and treatment of Nausea Vomit caused after surgery.
Last Update：2022-01-01 09:23:22
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CAS: 99614-02-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Ondansetron Visit Supplier Webpage Request for quotationCAS: 99614-02-5
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