Glycyrrhetic Acid 3-O-β-D-Glucuronide
Glycyrrhetic acid 3-O-mono-beta-D-glucuronide
CAS: 34096-83-8
Molecular Formula: C36H54O10
Glycyrrhetic Acid 3-O-β-D-Glucuronide - Names and Identifiers
Glycyrrhetic Acid 3-O-β-D-Glucuronide - Physico-chemical Properties
| Molecular Formula | C36H54O10 |
| Molar Mass | 646.81 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Melting Point | >200oC (dec.) |
| Boling Point | 785.0±60.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Powder |
| Color | Pale Yellow to Light Yellow |
| pKa | 2.82±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| In vitro study | Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC 50 value of 0.28 mM. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC 50 value of 120 μM in LPS‐induced RAW264.7 cells. |
Glycyrrhetic Acid 3-O-β-D-Glucuronide - Reference
| Reference Show more | 1. [IF=8.739] Jiajia Dong et al."Glycyrrhizin has a high likelihood to be a victim of drug–drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3."Brit J Pharmacol. 2018 Sep;175(17):3486-3503 2. [IF=4.749] Bin Wei et al."Highly Selective Entrapment of His-Tagged Enzymes on Superparamagnetic Zirconium-Based MOFs with Robust Renewability to Enhance pH and Thermal Stability."Acs Biomater Sci Eng. 2021;7(8):3727–3736 |
Glycyrrhetic Acid 3-O-β-D-Glucuronide - Reference Information
| Plant Source: | licorice |
| Overview | monoglucuronic acid glycyrrhetinic acid (GAMG) is a derivative of glycyrrhizic acid containing only one molecule of glucuronic acid, its polarity between glycyrrhizic acid and glycyrrhetinic acid, can smoothly enter the cell, in the body's solubility and transmembrane transport capacity than glycyrrhizic acid and glycyrrhetinic acid strong. Thus there is a better bioavailability. In the past 20 years, some foreign scholars have conducted a series of experimental studies on the anti-inflammatory, anti-allergic, anti-cancer and other physiological activities of GAMG, and have conducted a preliminary exploration on the mechanism of its anti-cancer efficacy, it was confirmed that both 18αGAMG and 18β-GAMG had strong anticancer effects. Therefore, the development of GAMG as an efficient new drug has broad application prospects. At the same time, GAMG, as a relatively safe new high-power sweetener, has broad application prospects in food additives. |
| preparation method | because the preparation process of GAMG is difficult, its application is limited. It is of great significance to independently screen new microbial strains that can produce GAMG by specific hydrolysis of GL. After mutagenesis by atmospheric pressure room temperature plasma (ARTP), an effective strain of the genus blue fungus capable of hydrolyzing GL to produce GAMG was screened, and the yield was high, and almost no by-products were generated. This not only provides a new direction for the industrial production of GAMG, but also simplifies the process and reduces the production cost, provides a new idea for the subsequent scale-up experiment and commercial production, and provides a new idea for the subsequent application of GAMG in food, medicine, cosmetics and other industrial fields to lay a solid foundation. |
| biological activity | glycorhetic acid 3-o-β-d-glucuronate is glycyrrhizic acid 3-o-β-d-glucuronic acid isolated from Glycyrrhiza uralensis Fisch, it is an important derivative of glycyrrhizin (GL). Glycorhetic acid 3-o-β-d-glucuronate (GAMG) indicates β-glucuronidase (β‐gus), a key GAMG-producing enzyme that can directly convert GL to GAMG. Glycorhetic acid 3-O-β-D-glucuronide is available as a sweetener. |
Last Update：2024-04-09 15:16:54
Supplier List
Multiple Specifications
Product Name: Enoxolone Impurity 11 Request for quotationCAS: 34096-83-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Glycyrrhetic acid 3-O-mono-beta-D-glucuronide Visit Supplier Webpage Request for quotationCAS: 34096-83-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: Enoxolone Impurity 11 Request for quotationCAS: 34096-83-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Glycyrrhetic acid 3-O-mono-beta-D-glucuronide Visit Supplier Webpage Request for quotationCAS: 34096-83-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History