H-ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2

Name	Pancreatic Polypeptide rat
Synonyms	PP, RAT Pancreatic Polypeptide rat Rat pancreatic polypeptide PANCREATIC POLYPEPTIDE, RAT APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY-NH2 ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2 H-ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2
CAS	90419-12-8

Molecular Formula	C195H298N58O57S1
Molar Mass	4398.87
Storage Condition	−20°C
MDL	MFCD00081813
In vitro study	Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM.
In vivo study	Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice.

WGK Germany

biological activity	Pancreatic Polypeptide, rat is a neuropeptide (NPY) receptor agonist and has a high affinity for NPYR4.
target	NPYR4
in vitro research	Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2) I levels in BRIN BD11 cells at 1 μ m.
in vivo research	Pancreatic Polypeptide (25 nmol/kg bw, I. p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mICE.

Last Update：2024-04-09 21:04:16

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CAS: 90419-12-8
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409

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