HDAC Inhibitor XXII, NCH51
PTACH
CAS: 848354-66-5
Molecular Formula: C20H26N2O2S2
HDAC Inhibitor XXII, NCH51 - Names and Identifiers
HDAC Inhibitor XXII, NCH51 - Physico-chemical Properties
| Molecular Formula | C20H26N2O2S2 |
| Molar Mass | 390.56 |
| Density | 1.181±0.06 g/cm3(Predicted) |
| Melting Point | 127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6)) |
| Solubility | DMSO: soluble26mg/mL |
| Appearance | White powder |
| pKa | 9.52±0.50(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21 WAF1/CIP1 in a dose-dependent manner. In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively. PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter. Western Blot Analysis Cell Line: HCT 116 cells Concentration: 1 μM, 5 μM, 25 μM Incubation Time: 8 hours Result: Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 WAF1/CIP1 . |
HDAC Inhibitor XXII, NCH51 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
HDAC Inhibitor XXII, NCH51 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.56 ml | 12.802 ml | 25.604 ml |
| 5 mM | 0.512 ml | 2.56 ml | 5.121 ml |
| 10 mM | 0.256 ml | 1.28 ml | 2.56 ml |
| 5 mM | 0.051 ml | 0.256 ml | 0.512 ml |
Last Update：2024-01-02 23:10:35
HDAC Inhibitor XXII, NCH51 - Reference Information
| biological activity | PTACH (NCH-51) is an effective HDAC inhibitor with IC50 of 48 nM,32 nM and 41 nM for HDAC1,HDAC4 and HDAC6 respectively. PTACH has a strong growth inhibitory effect on a variety of cancer cells (EC50 is 1.1-9.1 µM). |
| target | HDAC1 48 nM (IC 50 ) HDAC4 32 nM (IC 50 ) HDAC6 41 nM (IC 50 ) HIV-1 |
| in vitro study | PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21 WAF1/CIP1 in a Dose-dependent Manner. In Cancer Cell Growth inhibition Assay, PTACH (compound 51) Shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μ m, 9.1 μ m, 3.0 μ m, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively. PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter. Western Blot Analysis Cell Line: HCT 116 cells Concentration: 1 μ M, 5 μ M, 25 μ M Incubation Time: 8 hours Result: gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 WAF1/CIP1. |
| Cell Line: | HCT 116 cells |
| Concentration: | 1 μM, 5 μM, 25 μM |
| Incubation Time: | 8 hours |
| Result: | Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 WAF1/CIP1 . |
Last Update：2024-04-10 22:29:15
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Product Name: PTACH Visit Supplier Webpage Request for quotationCAS: 848354-66-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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