HEXYLLITHIUM, SOLUTION IN HEXANE
n-hexyllithium
CAS: 21369-64-2
Molecular Formula: C6H13Li
HEXYLLITHIUM, SOLUTION IN HEXANE - Names and Identifiers
| Name | n-hexyllithium |
| Synonyms | hexyllithium n-hexyllithium lithium,hexane 1-Lithiohexane 1-Hexyllithium Lithium, hexyl- HEXYLLITHIUM, SOLUTION IN HEXANE HEXYLLITHIUM SOLUTION, IN HEXANE HexyllithiuM, 2.5 M solution in Hexane, SpcSeal |
| CAS | 21369-64-2 |
| EINECS | 404-950-0 |
| InChI | InChI=1/C6H13.Li/c1-3-5-6-4-2;/h1,3-6H2,2H3;/rC6H13Li/c1-2-3-4-5-6-7/h2-6H2,1H3 |
HEXYLLITHIUM, SOLUTION IN HEXANE - Physico-chemical Properties
| Molecular Formula | C6H13Li |
| Molar Mass | 92.11 |
| Density | 0.708g/mLat 25°C |
| Boling Point | 69°C |
| Flash Point | 16°F |
| Vapor Presure | 26.9-39.3hPa at 20-35℃ |
| Color | yellow-brown |
| BRN | 3600261 |
| Storage Condition | 2-8°C |
| Stability | Stable, but highly flammable. Reacts violently with water, releasing flammable gas. May spontaneously inflame in air. Moisture and air sensitive. Incompatible with water, alcohols, halocarbons. |
| Sensitive | Moisture Sensitive |
HEXYLLITHIUM, SOLUTION IN HEXANE - Risk and Safety
| Risk Codes | R11 - Highly Flammable R14/15 - R17 - Spontaneously flammable in air R35 - Causes severe burns R48/20 - R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R62 - Possible risk of impaired fertility R65 - Harmful: May cause lung damage if swallowed R67 - Vapors may cause drowsiness and dizziness |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S30 - Never add water to this product. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S16 - Keep away from sources of ignition. S6 - Keep under ... (there follows the name of an inert gas). |
| UN IDs | UN 3394 4.2/PG 1 |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29319090 |
| Hazard Class | 4.3 |
| Packing Group | I |
HEXYLLITHIUM, SOLUTION IN HEXANE - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | organic lithium compounds are an important class of organometallic compounds. Ziegler was prepared by the reaction of organic halides with lithium metal and subsequently applied to organic synthesis. At present, as an important synthetic reagent, organic lithium compounds play an important role in basic theoretical research and industrial synthesis. Organolithium compounds are chemically similar to alkyl magnesium halides, but are more reactive, and can react with metal halides, carbonyl-containing species, halogenated hydrocarbons, and compounds containing active hydrogen. N-hexyl lithium is an important organic lithium compound, which can be used to remove many active hydrogen of hydrogen carbonate, and more important application is the hexylation of olefins. |
| Application | organic lithium compounds are generally prepared by preparing dispersions of lithium or lithium-sodium alloys in inert organic liquids, it is then prepared by adding a suitable alkyl halide, which is generally used in the form of a solution when used. In the prior art, n-hexyl lithium is obtained by reacting n-hexane chloride with 2 equivalents of lithium metal to obtain the product and lithium chloride. Generally, the reaction is carried out in an organic solvent, n-hexane, and in industrial production, the reaction of N-hexyl lithium easily takes place due to the scale-up benefit, and the Wurtz reaction and the disproportionation reaction are likely to obtain olefins. |
| preparation | n-hexyl lithium is prepared as follows: under the protection of argon, put 250L white oil and 21kg lithium tablets into a 500L reactor, slowly stir and raise the temperature to 180 ℃, stir for 130 r/min H, accelerate the stirring speed of the reaction kettle to 180, stir for 1H at ℃, turn on cooling to room temperature, press filtration to remove white oil, transfer n-hexane to the washing kettle, rinse 2-3 times to obtain a relatively uniform lithium metal morphology (lithium sand). Under the protection of argon, add 20kg of n-hexane to the 500L reactor, put 7kg of lithium sand and 58g L-proline under the condition of keeping the argon in the reactor outside, cover and maintain the positive pressure, open the vent valve to maintain the pressure balance, add 80kg of n-hexane to the reaction kettle, slowly turn on the stirring; Raise the temperature to 55 ℃, open the balance pipe valve, Dropwise add 60kg of n-hexane chloride, control the reaction kettle temperature at about 53-55 ℃; the reactor speed was controlled to 130 r/min. After dropping, start keeping warm for about 8 hours, cool down to room temperature and let stand still, filter with sand plate funnel, wash the reaction kettle and filtrate with n-hexane, N-hexyl lithium product 233L was obtained at a concentration of 89% m (yield). |
| Use | strong alkali; No gaseous by-product formation during reaction |
Last Update：2024-04-10 22:29:15
