HG 532
Phenprobamate
CAS: 673-31-4
Molecular Formula: C10H13NO2
HG 532 - Names and Identifiers
HG 532 - Physico-chemical Properties
| Molecular Formula | C10H13NO2 |
| Molar Mass | 179.22 |
| Density | 1.1248 (rough estimate) |
| Melting Point | 101-104° |
| Boling Point | 311.75°C (rough estimate) |
| Flash Point | 183.1°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 4.69E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 13.47±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5710 (estimate) |
| Physical and Chemical Properties | White shiny crystalline powder. Melting Point 101-104 ° C, soluble in ethanol, chloroform, propylene glycol and ethylenediamine, ether-soluble, almost insoluble in water. No odor, slightly bitter taste, slight numbness. |
| Use | For the treatment of muscle relaxation |
HG 532 - Risk and Safety
| Toxicity | LD50 orally in mice: 840 mg/kg (Stille) |
HG 532 - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Ethylene Oxide Toluene Benzyl Chloride Chlorosulfonic acid Magnesium Sodium cyanate Tetrahydrofuran |
| Downstream Products | Labetalol |
HG 532 - Reference
| Reference Show more | 1. Gan Xuewen, Wang Guangyao, Deng Shibin, etc. Content change and aroma effect of exogenous Maillard reaction intermediates in cigarette processing [J]. Food and machinery, 2017, 033(005):77-82. 2. [IF = 4.142] Zhang Wei et al."Proportional fluorescence and colorimetric dual-mode sensing platform based on carbon dots for detecting copper(II) ions and D-penicillamine." Anal Bioanal Chem. 2022 Feb;414(4):1651-1662 |
HG 532 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 1. High-potency sweetener-aspartame worldwide, the main use of L-Phenylalanine is to produce aspartame. Aspartame, also known as aspartame, domestic commonly known as protein sugar, is an excellent low-calorie sweetener, sweet and sucrose similar to the sweetness of sucrose 200 times, is currently the leading sweetener in the international market. Aspartame was first used as a sweetener in 1974; In 1981, FAO and WHO recommended an intake of aspartame of 40mg/person • day, compared with 50mg/person • day in the United States. In 1996, the United States allowed the use of albactam as a general sweetener in all foods without special regulations. The production and application of aspartame in China has just started and has great potential. At the end of the Eighties of the 20th century, China began to study aspartame, but because there was no L-phenylalanine production plant in China at that time, the price of imported raw materials was expensive, resulting in production costs could not compete with imported products, so there was no industrial production, market availability is limited. At present, China needs to consume 7.6 million t/a of sucrose per year. If 5% of sucrose is replaced by aspartame, aspartame is required to be about 1600t/a. Accordingly, the demand for L-phenylalanine will also increase. 2. According to the different uses in the field of medicine, L-phenylalanine has different grades such as pharmaceutical grade, food grade and feed grade, and the price of each grade is quite different, from $18/kg to $40/kg. L-phenylalanine can not only be directly used for medical compound amino acid infusion and synthetic medicine, but also can be used to prepare medical culture medium. Drugs synthesized by L-phenylalanine include HIV protease inhibitor, rennet, anti-tumor drug P-fluorophenylalanine, brain neurotransmitter, etc. The consumption demand of L-phenylalanine in this field is growing steadily. |
| purpose | This product is a skeletal muscle relaxant. Used for shoulder, neck stiff, lumbago, limb pain, muscle pain after exercise, contusion and torsion, rheumatoid arthritis, neuralgia and other muscle spasm often Nervousness each disease. for the treatment of muscle relaxation |
| production method | from 3-phenylpropanol and sodium cyanate condensation, hydrolysis. Anhydrous toluene, 3-phenylpropanol and sodium cyanate were added to the reaction tank, cooled to 10 °c, and hydrogen chloride gas was introduced under stirring for about 80min. The temperature rose to 55 °c and then began to decrease. After ventilation, the reaction was carried out at 55-60 ℃ for 0.5h. The mixture was cooled to 30 ° C., heated to 70 ° C. By adding aqueous ammonia, and allowed to stand for 0.5h. The organic layer was separated, filtered, and the filtrate was cooled to crystallize. The crystals were filtered and washed with toluene and then with distilled water until the chlorides met the requirements. Air drying, to get the phenyl propyl ester. |
Last Update：2024-04-09 20:45:29
Supplier List
Spot supply
Product Name: Phenprobamate Visit Supplier Webpage Request for quotationCAS: 673-31-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Phenprobamate Visit Supplier Webpage Request for quotationCAS: 673-31-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Phenprobamate Visit Supplier Webpage Request for quotationCAS: 673-31-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Phenprobamate Visit Supplier Webpage Request for quotationCAS: 673-31-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for HG 532
Downstream Products for HG 532