Name | HIV-1 Nef-IN-1 |
Synonyms | NSC-92828 HIV-1 Nef-IN-1 3-Phenanthrenebutyric acid 4-(3-phenanthryl)butanoic acid 4-(Phenanthren-3-yl)butanoic acid |
CAS | 13728-56-8 |
Molecular Formula | C18H16O2 |
Molar Mass | 264.32 |
Density | 1.211±0.06 g/cm3(Predicted) |
Melting Point | 138-139 °C |
Boling Point | 487.2±14.0 °C(Predicted) |
pKa | 4.76±0.10(Predicted) |
Storage Condition | -20℃ |
Use | HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM |
In vitro study | HIV-1 Nef-IN-1 (Compound D11; 20 μM) inhibits cell viability of COS7 cells, and the cell inhibition rate is 63.2%. |
Reference Show more | [1]. Stéphane Betzi, et al. Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.783 ml | 18.916 ml | 37.833 ml |
5 mM | 0.757 ml | 3.783 ml | 7.567 ml |
10 mM | 0.378 ml | 1.892 ml | 3.783 ml |
5 mM | 0.076 ml | 0.378 ml | 0.757 ml |