Hexaethylene Glycol Monobenzyl Ether

Hexaethylene Glycol Monobenzyl Ether - Names and Identifiers

Name	2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL
Synonyms	Benzyl-PEG7 BnO-PEG6-OH Benzyl-PEG6 HEXAETHYLENE GLYCOL MONOBENZYL ETHER 19-Phenyl-3,6,9,12,15,18-hexaoxanonadecan-1-ol 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol 2-[2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL
CAS	24342-68-5

Hexaethylene Glycol Monobenzyl Ether - Physico-chemical Properties

Molecular Formula	C19H32O7
Molar Mass	372.45
Density	1.097±0.06 g/cm3(Predicted)
Boling Point	473.6±40.0 °C(Predicted)
pKa	14.36±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.4920 to 1.4960
MDL	MFCD06797107
Physical and Chemical Properties	Bioactive BnO-PEG6-OH is a non-cleavable ADC linker containing 6-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). BnO-PEG6-OH is also a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules.
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Hexaethylene Glycol Monobenzyl Ether - Upstream Downstream Industry

Raw Materials

Hexaethylene glycol
Tosylate of Triethylene glycol monobenzyl ether
Benzyl chloride
Benzyl bromide
Triethylene glycol

Hexaethylene Glycol Monobenzyl Ether - Reference Information

biological activity	BnO-PEG6-OH is a non-cleavable ADC linker containing 6-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). BnO-PEG6-OH is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
target	Non-cleavable PEGs
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 01:59:58

Hexaethylene Glycol Monobenzyl Ether - Uses and synthesis methods

target

Non-cleavable PEGs

in vitro study

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 21:01:54