Hydroxyethyl Starch
Hydroxyethyl Starch
CAS: 9005-27-0
Molecular Formula: (C6H10O5)m(C2H5O)n
Hydroxyethyl Starch - Names and Identifiers
| Name | Hydroxyethyl Starch |
| Synonyms | hespanderinjection Hydroxyethyl Starch 2-HYDROXYETHYL STARCH 2-hydroxyethylstarchether Starch,2-hydroxyethyl ether |
| CAS | 9005-27-0 |
| EINECS | 618-410-9 |
| InChI | InChI=1/C16H32O11.C6H12O6/c17-1-6-22-11-12-13(23-7-2-18)14(24-8-3-19)15(25-9-4-20)16(27-12)26-10-5-21;7-1-2-3(8)4(9)5(10)6(11)12-2/h12-21H,1-11H2;2-11H,1H2/t12-,13-,14+,15-,16+;2-,3-,4+,5-,6+/m11/s1 |
Hydroxyethyl Starch - Physico-chemical Properties
| Molecular Formula | (C6H10O5)m(C2H5O)n |
| Molar Mass | 580.575 |
| Melting Point | >224oC (dec.) |
| Boling Point | 878.8°C at 760 mmHg |
| Flash Point | 485.3°C |
| Solubility | Freely soluble in water and in dimethyl sulfoxide, practically insoluble in anhydrous ethanol. Hydroxyethyl starches are hygroscopic until they reach a water content of about 12 per cent to 15 per cent. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White Powder |
| Color | White to Off-White |
| Storage Condition | -20°C，贮存于阴凉、干燥处，避免日晒、雨淋；有效贮存期12个月。按一般化学品运输。 |
| Physical and Chemical Properties | Hydroxyalkyl starch has high stability and non-ionic properties, is easy to gelatinize, has high transparency of the paste, good fluidity, weak coagulation, and high stability. It can still maintain its original colloidal structure when stored at low temperature or frozen and melted multiple times. The film is flexible and smooth, with good bending resistance, and due to the absence of micropores, it improves oil resistance. |
| Use | An ideal surface sizing agent and coating adhesive can effectively improve the physical properties of paper, such as wear resistance, texture, and smoothness. It can solve problems such as paper shedding and powder loss, inhibit ink penetration during printing, make the printing paper ink bright, uniform, and the adhesive film smooth, and reduce ink consumption. Hydroxyalkyl starch has hydrophilicity, which weakens the internal hydrogen bonding strength of starch particle structure. As the degree of substitution increases, the gelatinization temperature decreases and can eventually expand in cold water. Products with higher degrees of substitution can be soluble in methanol or ethanol. |
| Caution | Non toxic, with good biodegradability. Avoid contact with skin and eyes. If accidentally splashed into the eyes, lift the eyelids and rinse with running water or physiological saline. |
Hydroxyethyl Starch - Risk and Safety
| WGK Germany | 2 |
| RTECS | WI0410000 |
Hydroxyethyl Starch - Preparation method
Open Data Verified Data
Mix 950kg of 26% sodium chloride aqueous solution and 16kg of 30% sodium hydroxide evenly in a mixing tank for later use. Add 1050kg of 40% starch water lotion into the reactor, stir for 0.5h, add the above prepared salt and alkali mixed solution, then add 40kg ethylene oxide, seal the reactor, and stir at 38 ℃ for 24h. Neutralize the reaction solution with dilute hydrochloric acid to a pH of 6, filter and wash until no sodium chloride is present. Dry crushing and sieving to obtain products.
Last Update：2023-12-21 11:43:14
Hydroxyethyl Starch - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | Since the 30's of the 20th century, gelatin colloid plasma has been available, has been nearly 80 years of history. During the First World War, the invention of synthetic polyvinylpyrrolidone (PVP), World War II and the emergence of microbial synthesis of Dextran (Dextran), the United States developed in the mid-70s hydroxyethyl starch (hydroxyethyl starch, HES), china's Peking Union Medical College, Chinese Academy of Medical Sciences, blood transfusion and Blood Institute, in 1958 and 1967, respectively, the success of dextran and hydroxyethyl starch, and the rapid formation of industrialization in China, this has played an important role in the prevention and treatment of low blood volume and Shock patients in our country, and saved the life of counting. In clinical practice, hydroxyethyl starch is commonly used for volume therapy. After intravenous administration, it can rapidly increase blood volume. It is often used to treat Shock or hemorrhagic disease caused by massive hemorrhage, burns or other trauma, it can prevent the organ failure caused by the decrease of blood flow and oxygen supply of each organ caused by the circulatory disturbance caused by the reflux blood volume. |
| prescription application | has volume expansion effect and hemodilution effect. Clinical mainly for the treatment and prevention of insufficient blood circulation or Shock, such as hemorrhagic Shock, traumatic Shock, Infective Shock Shock, etc.; Can also be used for vascular occlusive vasculitis, cerebral thrombosis and myocardial infarction. The maximum dose was 33ml/(kg · d) and the maximum infusion rate was 20ml/(kg · h). The time and dose of treatment depends on the time and extent of hypovolemia. |
| purpose | blood volume expansion agent, used for various surgical and traumatic blood loss, fluid Infusion for toxic shock, etc. |
Last Update：2024-04-09 18:58:34
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Product Name: Hydroxyethyl starch (heta120k,MP=104,400) Visit Supplier Webpage Request for quotationCAS: 9005-27-0
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Product Name: Hydroxyethyl Starch Visit Supplier Webpage Request for quotationCAS: 9005-27-0
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QQ: 3008007409
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Multiple SpecificationsSpot supply
Product Name: Hydroxyethyl starch (heta120k,MP=104,400) Visit Supplier Webpage Request for quotationCAS: 9005-27-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Hydroxyethyl Starch Visit Supplier Webpage Request for quotationCAS: 9005-27-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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