Name | Tartronic acid |
Synonyms | C02287 NSC 36171 Tartronic acid TARTRONIC ACID HYDROXYMALONIC ACID hydroxypropanedioate Malonic Acid, Hydroxy- Malonic acid, hydroxy- hydroxypropanedioic acid Hydroxypropanedioic acid 2-Hydroxypropanedioic acid Propanedioic acid, hydroxy- Hydroxymalonic acid, Hydroxypropanedioic acid |
CAS | 80-69-3 |
EINECS | 201-301-1 |
InChI | InChI=1/C3H4O5/c4-1(2(5)6)3(7)8/h1,4H,(H,5,6)(H,7,8) |
InChIKey | ROBFUDYVXSDBQM-UHFFFAOYSA-N |
Molecular Formula | C3H4O5 |
Molar Mass | 120.06 |
Density | 1.2663 (rough estimate) |
Melting Point | 158-160 °C (dec.) (lit.) |
Boling Point | 471.4±30.0 °C(Predicted) |
Flash Point | 253°C |
Water Solubility | Soluble in water and alcohol. |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Vapor Presure | 7.22E-11mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Merck | 14,9073 |
BRN | 1209791 |
pKa | 2.42, 4.54(at 25℃) |
Storage Condition | 2-8°C |
Refractive Index | 1.4000 (estimate) |
MDL | MFCD00004237 |
Physical and Chemical Properties | Colorless prismatic crystals. Generally containing 1 molecules of crystal water, the loss of crystal water at 60 deg C, 110 deg C sublimation. Melting point 141-142 °c, 156-158 °c (rapid heating). Soluble in water, alcohol, anhydrous can dissolve in ether, containing crystal water is difficult to dissolve in ether. |
Hazard Symbols | Xi - Irritant |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Overview | tartaric acid is a high value-added chemical that is widely used in the pharmaceutical field, it can inhibit the conversion of carbohydrate into fat in the human body, prevent the accumulation of fat in the body, and has the effect of losing weight and preventing coronary heart disease. |
pharmacological studies | Modern pharmacological studies have shown that cucumber fruit contains tartaric acid, which can prevent the accumulation of fat in the human body, have the effect of weight loss and prevention of coronary heart disease. The astringent taste of Cucumber mainly comes from tartaric acid contained in cucumber, which is not contained in other common vegetables. The fusion of tartaric acid and saliva has a slightly astringent taste. |
Use | for organic synthesis. |
production method | using diethyl malonate as a raw material, bromine is first added under illumination, and diethyl malonate bromide is distilled under reduced pressure to obtain diethyl malonate bromide. Potassium hydroxide solution was then added, hydrolyzed by heating at reflux for 4H and neutralized to pH 5 with acetic acid. Barium chloride solution was added to form barium hydroxymalonate. After acidification, it was distilled under reduced pressure, extracted with ether, and finally refined with acetic acid to obtain a finished product. |