IR microencapsulated Ferrous fumarate
Iron(II) fumarate
CAS: 141-01-5
Molecular Formula: C4H2FeO4
IR microencapsulated Ferrous fumarate - Names and Identifiers
| Name | Iron(II) fumarate |
| Synonyms | Ironfumarate IRON FUMARATE IRON(+2)FUMARATE Iron(Ⅱ) fumarate Ferrius fumarate FERROUS FUMARATE Ferrous Fumarate IRON(II) FUMARATE Iron(II) fumarate iron(2+) (2E)-but-2-enedioate IR microencapsulated Ferrous fumarate |
| CAS | 141-01-5 |
| EINECS | 205-447-7 |
| InChI | InChI=1/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2 |
| InChIKey | PMVSDNDAUGGCCE-TYYBGVCCSA-L |
IR microencapsulated Ferrous fumarate - Physico-chemical Properties
| Molecular Formula | C4H2FeO4 |
| Molar Mass | 169.9 |
| Density | 2.435 |
| Melting Point | >280°C |
| Water Solubility | Soluble in water (0.14 g/100 ml at 25°C). |
| Solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent). |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | solid |
| Color | Dark Red to Dark Brown |
| Exposure Limit | ACGIH: TWA 1 mg/m3NIOSH: TWA 1 mg/m3 |
| Merck | 14,4046 |
| Storage Condition | Refrigerator |
| Stability | Stability |
| MDL | MFCD00058315 |
| Physical and Chemical Properties | Density 2.435 melting point> 280°C |
| Use | Anti-anemia drugs for the treatment of iron deficiency anemia, but also a large number of food and feed additives |
IR microencapsulated Ferrous fumarate - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | LT1950000 |
| TSCA | Yes |
| HS Code | 29171900 |
| Toxicity | LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum) |
IR microencapsulated Ferrous fumarate - Reference Information
| LogP | 0.62 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| organic iron supplement | iron is one of the essential trace elements in animal body. It is a component of heme, myoglobin, cytochrome, etc., and is closely related to the processes of hematopoiesis, oxygen carrying, and production capacity of animals. When animals synthesize somatic proteins, they need the effect of nylin, and iron is an essential substance for the synthesis of nylin. When animals lack iron, the first manifestations are growth retardation, weak disease resistance, reduced feed utilization, and poor reproductive ability, followed by anemia, diarrhea, and death. Ferrous fumarate, also known as ferric fumarate, is a safe and efficient organic nutritional iron supplement. It belongs to organic iron (including: iron lysine, iron glycinate, iron methionine, etc.), Its organic divalent iron content is as high as 30% or more. After ferrous fumarate is absorbed, the divalent iron ions are easier to decompose. It does not require additional energy to enter red blood cells, does not stimulate the intestines and stomach, and can improve and maintain the normal level of heme, it can be used as a nutritional additive for a long time and clinically used to treat iron deficiency anemia. Ferrous fumarate is absorbed in the duodenum and upper jejunum in the form of ferrous ions in animals. Most of the absorbed iron is involved in the synthesis of hemoglobin in the bone marrow, and the remaining part is stored in the reticuloendothelial cells of the bone marrow, liver and spleen in the form of ferritin and hemosiderin, and a part exists in the intestinal mucosal cells. This absorption method is different from inorganic iron supplements (ferrous sulfate, ferrous carbonate, iron oxide, etc.). It can alleviate the competitive antagonism between trace elements during absorption, does not destroy vitamins, and does not catalyze oxidation The reaction has good compatibility with various nutrients and can smoothly pass the body's absorption barrier, which not only greatly improves the absorption and utilization of iron, but also increases the absorption rate of other elements. The main route of iron excretion is intestinal and skin, urine and sweat glands also have a small amount of excretion. Most iron can be reused when hemoglobin molecules are released after being destroyed. |
| identification test | take about 1.5g of sample, add 25ml of 1:1 dilute hydrochloric acid, dilute to 50ml with water, heat to completely dissolve, cool, filter with a fine-hole sintered glass crucible, wash the precipitate with 3% dilute hydrochloric acid, save the filtrate for identification test 2, and dry the filter residue at 105 ℃. Add 3m1 water and 7 mL1mol/L sodium hydroxide to 400mg of dry filter residue and stir until completely dissolved. Dilute hydrochloric acid test solution (TS-117) is added dropwise until the solution is just acidic to litmus paper, and 1g of p-nitrobenzyl bromide and 10ml of ethanol are added to heat and reflux the mixed solution for 2 hours. After cooling, filter, rinse the filter residue twice with a small amount of ethanol and water mixture (2:1), and then rinse twice with a small amount of water. It is recrystallized and precipitated by hot ethanol and dried at 105 ℃, with a melting point of about 152 ℃. Part of the filtrate from the above test was positive for iron test (IT-19). |
| content analysis | accurately weigh the sample about 500mg, move into a 500ml conical flask, add 25mi,2:3 dilute hydrochloric acid, and heat to boiling. Drop the solution prepared by dissolving 5.6g of stannous chloride in 50ml and 1:2 dilute hydrochloric acid until yellow has faded, and add another 2 drops in excess. The solution is cooled to room temperature in an ice bath, and 8ml of mercury chloride test solution (TS-138) is added and placed for 5min. Add 200ml of water, 25mL 50% dilute sulfuric acid and 4m1 phosphoric acid, add several drops of n-phenanthroline test solution (TS-162), and titrate with 0.1mol/L high cerium sulfate. Cerium sulfate is equivalent to ferrous fumarate (C4H2FeO4)16.99mg per ml0.1mol/L. |
| toxicity | LD503850mg/kg (rat, oral). GRAS(FDA,§ 184.1307d,2000). |
| usage limit | GB 14880-94(mg/kg): 70~150 of cereals and their products; Beverage 30~60; Dairy products, infant food 180~300; Salt and sandwich sugar 1800~3600.GB 2760-2002(mg/100g): Cocoa powder and other nutritious solid beverages, 11-22 (in terms of iron; The amount of equivalent nutritious milk beverage is reduced by dilution ratio); Milk-containing solid beverage 28.9~38. |
| use | ferrous fumarate is used as a food iron fortifier with better absorption effect than inorganic iron. China stipulates that it can be used for salt and sandwich sugar, and the usage amount is 1800~3600 mg/kg; 520~580 mg/kg in high-iron cereals and their products (50g of such foods are limited daily); 180~300 mg/kg in dairy products and infant food; 70~150 mg/kg in cereals and their products; 30~60 mg/kg in beverages. Antianemia drugs are used to treat iron deficiency anemia, and are also widely used in food and feed additives Ferrous fumarate is used as a food iron fortifier, and the absorption effect is better than inorganic iron. China stipulates that it can be used for salt and sandwich sugar, with a usage of 1800-1600mg/kg; 520-580mg/kg in high-iron cereals and their products (50g of such foods are limited daily); 180-300mg/kg in dairy products and infant food; 70-150mg/kg in cereals and their products; 30-60mg/kg in beverages. Nutritional supplement (iron fortifier). Ferrous fumarate is an anti-anemia drug. Anemia is divided into iron deficiency anemia, megaloblastic anemia and aplastic anemia according to different causes. Ferrous fumarate is used to treat iron deficiency anemia. It has high iron content, good absorption, and is difficult to be oxidized into trivalent iron. After taking it, the serum iron value rises quickly and can remain stable. The oral LD50 of mice is 480mg/kg. |
| Production method | It is obtained by replacing sodium fumarate with ferrous sulfate. Heat the water to boiling, add fumaric acid under stirring, and add sodium carbonate to pH = 6.5-6.7. After full stirring, filter while hot to obtain sodium fumarate solution. Add ferrous sulfate solution, stir, heat and reflux for 3-4h, cool and crystallize, and filter. The filter cake is washed with distilled water until the sulfate radical meets the requirements, and dried to obtain ferrous fumarate with 83% yield. It is obtained by the reaction of fumaric acid and iron filings. add 5g of fumaric acid into 100mL of boiling water and neutralize it with sodium carbonate until PH6.5-6.7; Filtration, adding 13g of ferrous sulfate and 100mL of water solution to the obtained disodium fumarate solution, and heating, stirring and refluxing (100 ℃) for 3-4h; Finally, red-brown powder ferrous fumarate 6.2-6.6g was obtained by cooling, crystallization, filtration, washing and drying, with a yield of 85%-90%. add 5g of fumaric acid into 100mL of boiling water and neutralize with sodium carbonate until the Ph value is 6.5-6.7; Filtration, adding 13g of ferrous sulfate and 100mL of water solution to the obtained disodium fumarate solution, heating, stirring and refluxing (100 ℃) for 3-4h; Finally, cooling, crystallization, filtration, washing and drying obtain red-brown powder ferrous fumarate 6.2-6.6g with a yield of 85%-90%. C4H4O4+Na2CO3→C4H2O4Na2+H2O+CO2↑FeSO4+Na2C4H2O4→Na2SO4+FeC4H2O4 |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral administration-rat LD50 3850 mg/kg; Oral administration-mouse LD50: 1570 mg/kg |
| flammability hazard characteristics | combustible; combustion releases smoke stimulated by iron oxide |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
| occupational standard | TWA 1 mg (iron)/m3 |
Last Update：2024-04-09 21:21:28
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