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Iloprost (for research only)

Iloprost

CAS: 73873-87-7;78919-13-8

Molecular Formula: C22H32O4

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Iloprost (for research only) - Names and Identifiers

Name Iloprost
Synonyms Ilopros
ILOPROST
Iloprost
Ciloprost
CILOPROST
Iloprost (for research only)
6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID
(5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
(5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
CAS 73873-87-7
78919-13-8
InChI InChI=1/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18?,19-,20+,21+/m0/s1

Iloprost (for research only) - Physico-chemical Properties

Molecular FormulaC22H32O4
Molar Mass360.49
Density1.21g/cm3
Boling Point539.2°C at 760 mmHg
Flash Point294°C
Solubility Chloroform (Slightly), Methanol (Slightly)
Vapor Presure7.06E-14mmHg at 25°C
AppearanceSolid
ColorColourless to Pale Yellow Oil to
Storage ConditionAmber Vial, -20°C Freezer, Under inert atmosphere
StabilityLight Sensitive
Refractive Index1.629

Iloprost (for research only) - Preparation solution concentration reference

 1mg5mg10mg
1 mM2.774 ml13.87 ml27.74 ml
5 mM0.555 ml2.774 ml5.548 ml
10 mM0.277 ml1.387 ml2.774 ml
5 mM0.055 ml0.277 ml0.555 ml
Last Update：2024-01-02 23:10:35

Iloprost (for research only) - Reference Information

usage and dosage adult: each inhalation should start from 2.5 micrograms (the dose provided by the mouthholder in the inhalation device). According to the needs and tolerability of different patients, iloprost should be inhaled 6-9 times a day. Depending on the dose of the drug required for the mouthpart and nebulizer, each inhalation time should be approximately 5-10 minutes.
Course of treatment: long-term treatment.
use of atomizer: the median aerodynamic diameter (MMAD) or median diameter (MMD) of the droplet is 3-4 m; The output dose of the mouthpiece is: 2.5 or 5 ug of iloprost each time; The atomization time of iloprost with a dose of 2.5 or 5 ug is about 4-10 minutes (in order to avoid systemic side effects, the output of iloprost within 4 minutes shall not exceed 5 ug). In order to minimize accidental exposure, it is recommended to use an atomizer equipped with a filter or inhalation trigger device when inhaling iloprost, and to maintain good ventilation in the room. Inhale the prepared solution with appropriate equipment (nebulizer).
pharmacological effects pulmonary hypertension is mainly characterized by increased pulmonary vascular resistance, and its pathogenesis includes vasoconstriction, vascular remodeling and thrombosis. Iloprost can stimulate adenylate cyclase, increase the concentration of cAMP in smooth muscle cells, and then dilate blood vessels. In addition, studies have shown that prostacyclin antagonizes the production and secretion of endothelin, inhibits platelet aggregation, and inhibits cell migration and proliferation. Regardless of intravenous or inhalation treatment of pulmonary hypertension, it is important to avoid uneven drug distribution leading to imbalance of ventilatory blood flow ratio and aggravating hypoxemia. The anatomical characteristics of the alveoli-capillaries determine that the drug can work through inhalation. Iloprost inhaler is a selective pulmonary vasodilator. Because the pre-capillary resistance blood vessel is surrounded by the alveoli, the local concentration of the alveoli after inhalation Higher, it directly acts on the sphincter and smooth muscle cells of the pre-capillary resistance blood vessel through diffusion, so it has a targeted therapeutic effect that other pathways cannot match.
Last Update：2024-04-10 22:29:15
Iloprost (for research only)
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 78919-13-8
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Taizhou Crene Biotechnology Co., Ltd.
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CAS: 78919-13-8
Tel: 0576-88813233
Email: sales@crene.cn
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Iloprost Request for quotation
CAS: 78919-13-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: ILOPROST Visit Supplier Webpage Request for quotation
CAS: 78919-13-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Taizhou Crene Biotechnology Co., Ltd.
Product Name: Iloprost Request for quotation
CAS: 78919-13-8
Tel: 0576-88813233
Email: sales@crene.cn
Mobile: 13396922869
QQ: 9246768 Click to send a QQ messageSend QQ message
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Iloprost (for research only)
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