Imipenem hydrate
(6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2.0]OCT-2-ene-2-carboxylic acid monohydrate
CAS: 74431-23-5
Molecular Formula: C16H25N2O5S.C12H18N4O4.Na
Imipenem hydrate - Names and Identifiers
| Name | (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2.0]OCT-2-ene-2-carboxylic acid monohydrate |
| Synonyms | Imipenem hydrate Imipenem monohydrate (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2.0]OCT-2-ene-2-carboxylic acid monohydrate 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,6-(1-hydroxyethyl)-3-[[2-(iminomethyl)amino]ethyl]thio]-7-oxo-,monohydrate (5R,6S)-3-[(2-{[(1E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate |
| CAS | 74431-23-5 |
| EINECS | 264-734-5 |
| InChI | InChI=1/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1 |
Imipenem hydrate - Physico-chemical Properties
| Molecular Formula | C16H25N2O5S.C12H18N4O4.Na |
| Molar Mass | 662.74 |
| Melting Point | 193-198°C |
| Boling Point | 567.3°C at 760 mmHg |
| Flash Point | 296.9°C |
| Water Solubility | Soluble in water at 5mg/ml |
| Vapor Presure | 3.11E-15mmHg at 25°C |
| Appearance | Shape powder, color white to beige |
| pKa | pKa 3.2/9.9(H2O,t = 25) (Uncertain) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Physical and Chemical Properties | Chemical properties crystallize from water-ethanol. [α]D23 +86.8 (C = 0.05,0.1mol/L, phosphate buffer, Ph = 7). PKal is about 3.2 and pKa2 is about 9.9. UV maximum absorption (water):299nm(ε9670,98% hydroxylamine extraction). Solubility (mg/m1): water 10, methanol 5, ethanol 0.2, acetone <0.1, dimethylformamide <0.1, dimethyl sulfoxide 0.3. |
| Use | Uses carbapenem extended-spectrum β-lactam antibiotics, is a semi-synthetic derivative of thiomycin, antibacterial spectrum and the role of use and thiomycin similar, but more stable than thiomycin. And other antibiotics are not cross-resistant, but vulnerable to renal peptidase destruction, and renal peptidase inhibitors (such as cilastatin sodium) is often used. Stable to beta-lactamase. For urinary tract infections, lower respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, digestive system infections, osteomyelitis, prostatitis, bacteremia. |
Imipenem hydrate - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2941906000 |
Imipenem hydrate - Upstream Downstream Industry
Imipenem hydrate - Reference
| Reference Show more | 1. [IF=3.681] Rao Zhi et al."Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients."Ther Drug Monit. 2020 Aug;42(4):578-587 |
Supplier List
Spot supply
Product Name: Imipenem Visit Supplier Webpage Request for quotationCAS: 74431-23-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Imipenem Visit Supplier Webpage Request for quotationCAS: 74431-23-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for Imipenem hydrate
Ammonium chloride
Iodomethane
6-Aminopenicillanic acid
Sodium bisulfite water solution
Trimethacrylate
MERCURIC ACETATE
VINYLACETIC ACID
INSTANT BUFFER S70, PH7.0 (ACC. TO SOERENSEN)(50PACKS)
Iodomethane
6-Aminopenicillanic acid
Sodium bisulfite water solution
Trimethacrylate
MERCURIC ACETATE
VINYLACETIC ACID
INSTANT BUFFER S70, PH7.0 (ACC. TO SOERENSEN)(50PACKS)