Irbesartan impurity A (EP)

Irbesartan impurity A (EP) - Names and Identifiers

Name	1-(Pentanoylamino)-N-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]cyclopentanecarboxamide
Synonyms	Irbesartan EP Impurity A Irbesartan impurity A (EP) N-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1-pentanamidocyclopentanecarboxamide 1-(Pentanoylamino)-N-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]cyclopentanecarboxamide N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentanecarboxamide 1-(pentanoylamino)-N-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]cyclopentane-1-carboxamide Irbesartan ImpurityI (1-pentanoylamino-cyclopentanecarboxylic acid [2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide) Irbesartan Related Compound A (25 mg) (1-pentanoylaminocyclopentanecarboxylic acid [2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide) IRBESARTAN RELATED COMPOUND A (25 MG) (1-PENTANOYLAMINO-CYCLOPENTANECARBOXYLIC ACID [2'-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-AMIDE)
CAS	748812-53-5

Irbesartan impurity A (EP) - Physico-chemical Properties

Molecular Formula	C25H30N6O2
Molar Mass	446.54
Density	1.26
Appearance	neat
pKa	4.16±0.10(Predicted)
Storage Condition	2-8°C

Irbesartan impurity A (EP) - Risk and Safety

HS Code

2933998350

Irbesartan impurity A (EP) - Introduction

Impurity A(EP) of irbesartan, chemical name 1-(pentanamido)-N-[[2 '-(1h-tetrazol-5-yl) biphenyl-4-yl] methyl] cyclopentane carboxamide, an impurity of a pharmaceutical raw material.

The properties of irbesartan impurity A are as follows:
-Appearance: White solid
-Molecular formula: C27H31N5O2
-Molecular weight: 461.57g/mol
-Melting point: about 170-174 ° C
-Solubility: Slightly soluble in water, ethanol and chloroform, insoluble in ether

The main use of irbesartan impurity A is as A reference substance for drug quality control, and is used for quality evaluation and analysis of irbesartan raw materials and preparations.

The preparation method of irbesartan impurity A is mainly synthesized by organic synthesis method. The specific synthesis method is as follows:
1. Benzaldehyde reacts with carbon tetrachloride to obtain benzoyl chloride.
2. Benzoyl chloride reacts with 1-pentylamine to generate benzamide.
3. Reacting benzamide with diethyl phthalate to obtain dibenzamide phthalate.
4. Reacting phthalic acid dibenzamide with N-anhydride-N'-carbonyl L-lysine ethyl ester to produce L-lysine benzamide.
5. The reaction of L-lysine benzamide with tetraaromatic sodium to generate irbesartan raw material.

The safety information of irbesartan impurity A is limited, and it needs to be used and operated in strict accordance with safety procedures. It is important to confirm the purity of the chemicals and to take the necessary personal protective measures. To use irbesartan impurity A, follow the safety guidelines for handling and storage of the relevant chemicals.

Last Update：2024-04-09 18:58:34