Name | 6-methoxylisoquinoline |
Synonyms | 6-methoxyisoquinoline 6-METHOXY-ISOQUINOLINE 6-Methoxy-Isoquinoline 6-methoxylisoquinoline Isoquinoline, 6-methoxy- 6-Methoxy-2-azanaphthalene |
CAS | 52986-70-6 |
Molecular Formula | C10H9NO |
Molar Mass | 159.18 |
Density | 1.130±0.06 g/cm3(Predicted) |
Boling Point | 88-95?C/0.8 Torr |
Solubility | Chloroform, Dichloromethane |
Appearance | Solid |
Color | Pale Yellow |
pKa | 6.11±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
MDL | MFCD04114861 |
Hazard Symbols | Xi - Irritant |
Hazard Note | Irritant |
introduction | 6-methoxyisoquinoline is transparent and can be used as an intermediate in pharmaceutical synthesis and used in pharmaceutical synthesis. |
Preparation | Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxy-p-phenylethylamine is obtained through condensation with nitromethane Shiff base and aluminum hydride reduction. 3-methoxy-p-phenethylamine was Pictet-Spengler with 40% aqueous formaldehyde to prepare 6-methoxy-1, 2,3, 4-tetrahydroisoquinoline, and then the target compound 6-methoxyisoquinoline was obtained by dehydrogenation. The synthesis reaction formula is as follows: |