Isoxazole, 5-phenyl-
5-Phenyl-1,2-oxazole
CAS: 1006-67-3
Molecular Formula: C9H7NO
Isoxazole, 5-phenyl- - Names and Identifiers
| Name | 5-Phenyl-1,2-oxazole |
| Synonyms | 5-PHENYLISOXAZOLE Isoxazole, 5-phenyl- 5-Phenyl-1,2-oxazole 1-(Isoxazol-5-yl)benzene |
| CAS | 1006-67-3 |
Isoxazole, 5-phenyl- - Physico-chemical Properties
| Molecular Formula | C9H7NO |
| Molar Mass | 145.16 |
| Density | 1.138 g/cm3(Temp: 24 °C) |
| Melting Point | 22°C(lit.) |
| Boling Point | 260°C(lit.) |
| Appearance | powder to lump to clear liquid |
| Color | White or Colorless to Almost white or Almost colorless |
| Maximum wavelength(λmax) | ['260nm(EtOH)(lit.)'] |
| pKa | -3.02±0.50(Predicted) |
| Storage Condition | 2-8°C |
Isoxazole, 5-phenyl- - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Note | Irritant |
Isoxazole, 5-phenyl- - Introduction
5-Phenyl-1,2-oxazole is an organic compound with the chemical formula C9H7NO. It is a white to pale yellow solid with a smoky musk-like odor.
The following is an introduction to the nature, use, preparation and safety information of 5-Phenyl-1,2-oxazole:
Nature:
1. Melting point: 71-72°C
2. Boiling point: 318°C
3. density: 1.20g/cm³
4. Soluble in ethanol, ether and chlorinated hydrocarbons, slightly soluble in water.
Use:
1. 5-Phenyl-1,2-oxazole is an important organic synthesis intermediate, which can be used to synthesize compounds with biological activity.
2. It has a wide range of applications in the field of pesticides, pharmaceuticals and dyes.
Preparation Method:
There are many preparation methods of 5-Phenyl-1,2-oxazole. One commonly used method is to react p-nitrobenzene and tert-butyl alcohol under alkaline conditions. The specific steps are as follows:
(1) p-Nitrobenzene and tert-butyl alcohol were mixed and esterified under alkaline conditions to produce p-tert-butoxycarbonylaniline.
(2) p-tert-butoxycarbonyl aniline is subjected to dehydration cyclization reaction to generate 5-Phenyl-1,2-oxazole.
Safety Information:
The safety of 5-Phenyl-1,2-oxazole is not fully understood, so appropriate safety measures need to be taken when using it. It may be irritating to the skin and eyes, so contact should be avoided when handling. In addition, it may also have a certain impact on the environment, so the relevant environmental regulations should be observed when disposing of waste. When using and storing, please refer to the product's safety data sheet and relevant regulations.
The following is an introduction to the nature, use, preparation and safety information of 5-Phenyl-1,2-oxazole:
Nature:
1. Melting point: 71-72°C
2. Boiling point: 318°C
3. density: 1.20g/cm³
4. Soluble in ethanol, ether and chlorinated hydrocarbons, slightly soluble in water.
Use:
1. 5-Phenyl-1,2-oxazole is an important organic synthesis intermediate, which can be used to synthesize compounds with biological activity.
2. It has a wide range of applications in the field of pesticides, pharmaceuticals and dyes.
Preparation Method:
There are many preparation methods of 5-Phenyl-1,2-oxazole. One commonly used method is to react p-nitrobenzene and tert-butyl alcohol under alkaline conditions. The specific steps are as follows:
(1) p-Nitrobenzene and tert-butyl alcohol were mixed and esterified under alkaline conditions to produce p-tert-butoxycarbonylaniline.
(2) p-tert-butoxycarbonyl aniline is subjected to dehydration cyclization reaction to generate 5-Phenyl-1,2-oxazole.
Safety Information:
The safety of 5-Phenyl-1,2-oxazole is not fully understood, so appropriate safety measures need to be taken when using it. It may be irritating to the skin and eyes, so contact should be avoided when handling. In addition, it may also have a certain impact on the environment, so the relevant environmental regulations should be observed when disposing of waste. When using and storing, please refer to the product's safety data sheet and relevant regulations.
Last Update：2024-04-09 20:52:54
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CAS: 1006-67-3
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CAS: 1006-67-3
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