Name | L(+)-Lactic acid |
Synonyms | L-Lactic acid L(+)-Lactic acid L(+)-Lactic Acid SARCOLACTIC ACID (S)-(+)-LACTIC ACID 2-HYDROXYPROPIONIC ACID L-Lactic acid, free acid L(+)-Lactic acid solution L-2-HYDROXYPROPIONIC ACID (S)-2-HYDROXYPROPIONIC ACID (S)-2-Hydroxypropionic acid L-(+)-2-HYDROXYPROPANOIC ACID (S)-(+)-2-HYDROXYPROPANOIC ACID (S)-(+)-2-Hydroxypropanoic acid L(+)lactic acid free acid sigmaultra |
CAS | 79-33-4 |
EINECS | 201-196-2 |
InChI | InChI=1/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1 |
InChIKey | JVTAAEKCZFNVCJ-REOHCLBHSA-N |
Molecular Formula | C3H6O3 |
Molar Mass | 90.08 |
Density | 1.206g/mLat 25°C |
Melting Point | 52-54°C |
Boling Point | 125 °C |
Specific Rotation(α) | -13.5 º (c=2.5, 1.5N NaOH) |
Flash Point | >230°F |
JECFA Number | 930 |
Water Solubility | SOLUBLE |
Solubility | It can be mixed with water, ethanol or ether at will and is insoluble in chloroform. |
Vapor Presure | 0.038Pa at 25℃ |
Appearance | Powder/Solid |
Color | White |
Merck | 14,5337 |
BRN | 1720251 |
pKa | pK at 25°, 3.79 |
Storage Condition | 2-8°C |
Sensitive | Hygroscopic |
Refractive Index | n20/D 1.427 |
MDL | MFCD00064266 |
Physical and Chemical Properties | Colorless, clear, viscous liquid, slightly sour; Hygroscopicity, acidic reaction in aqueous solution. It can be mixed with water, ethanol or ether and is insoluble in chloroform. density 1.206 boiling point 125°C refractive index 1.426-1.428 specific optical rotation -13.5 ° (c = 2.5, 1.5N NaOH) water-SOLUBLE solution |
Use | Mainly used as a food acid and preservatives, as well as for the manufacture of calcium lactate and other drugs |
Risk Codes | R38 - Irritating to the skin R41 - Risk of serious damage to eyes R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R35 - Causes severe burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
UN IDs | 3261 |
WGK Germany | 1 |
RTECS | OD2800000 |
FLUKA BRAND F CODES | 3-10 |
TSCA | Yes |
HS Code | 29181100 |
Hazard Class | 8 |
Packing Group | III |
Toxicity | LD50 intraperitoneal in mouse: 3194mg/kg |
Raw Materials | Starch potato |
Downstream Products | dl-lactic acid sodium salt Fenoxaprop-ethyl Ethyl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate Calcium lactate |
FEMA | 2611 | LACTIC ACID |
LogP | -0.54 at 20℃ |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Application | L-lactic acid is an organic acid that melts with mammals and is a colorless or yellowish viscous liquid, widely used in food, wine, beverage, medicine, leather, feed, plastic chemical, pesticide and other fields, the series of products: such as calcium lactate, can prevent calcium deficiency; Sodium lactate, for gastrointestinal fluid; magnesium lactate, for the treatment of magnesium deficiency patients; Iron lactate, for the treatment of iron deficiency anemia, as well as ferrous lactate, zinc lactate. |
biological activity | L-Lactic acid is a natural product that can be used as a food additive. |
Use | mainly used as a acidulant and preservative in food, and for the manufacture of calcium lactate and other drugs , high purity, good thermal stability, is a natural acid, PH regulator and preservatives. 98% high purity L-(+)-lactic acid is used as lactate dehydrogenase and lactate oxidase substrate |
production methods | the industrial methods for producing lactic acid mainly include fermentation, acetaldehyde and acrylonitrile. In the fermentation method, sucrose, beet sugar or its molasses, which is a raw material containing starch, is used as a raw material. Saccharification of lactic acid bacteria strains. The pH is controlled at 5-5.5, and the temperature is about 50 ° C. For 3-4 days, and the generated lactic acid is converted into calcium lactate with calcium carbonate. At the same time to prevent the pH value to reduce the impact of fermentation, while hot filtration separation in the solution of solid calcium carbonate and calcium hydroxide, etc., refined calcium lactate. The resulting lactic acid and calcium sulfate precipitates were acidified with sulfuric acid and filtered. The filtrate contained approximately 10% crude lactic acid and was concentrated to 50%. Then the organic impurities were removed by activated carbon, and the heavy metals and condensed impurities were removed by sodium ferrocyanide. Finally, the ion exchange resin was used to remove trace impurities, and then concentrated and filtered to obtain the product. Raw material consumption quota: Rice 2080kg/t, sulfuric acid (98%)530kg/t. Acetaldehyde-hydrocyanic acid method crude lactic acid was obtained by the reaction of acetaldehyde with hydrocyanic acid to produce lactonitrile, which was hydrolyzed. The crude lactic acid is esterified with ethanol to produce lactic acid ester, which is then decomposed into lactic acid. The acetaldehyde and the cooled hydrocyanic acid are continuously fed into the reactor to generate milk nitrile, which is then pumped into the hydrolysis kettle, and sulfuric acid and water are injected to hydrolyze the milk nitrile to obtain crude lactic acid. The crude lactic acid is sent into the esterification kettle to add ethanol, and the esterification is generated to lactic acid ester. After rectification, and then into the decomposition and concentration tank heat decomposition to obtain refined lactic acid. Raw material consumption quota: acetaldehyde 480kg/t, hydrocyanic acid 290kg/t, sulfuric acid 1040kg/t. 3. Acrylonitrile method with acrylonitrile as raw material and sulfuric acid reaction to generate crude lactic acid, and then with methanol reaction to generate methyl lactate, by distillation to obtain crude ester, refined Ester heat decomposition to lactic acid. Acrylonitrile and sulfuric acid were fed to the reactor to produce a mixture of crude lactic acid and ammonium bisulfate. The mixture is then fed to an esterification reaction apparatus to react with methanol to produce methyl lactate. After the ammonium bisulfate was separated, the crude ester was sent to the distillation column, and the refined Ester was obtained at the bottom of the column. The refined Ester was sent to the second distillation column, heated and decomposed, and the dilute lactic acid was obtained at the bottom of the column, and the product was obtained by vacuum concentration. The finished lactic acid is divided into reagent grade, drug grade, edible export grade and edible domestic grade according to the purpose. Raw material consumption quota: acrylonitrile 780kg/t, sulfuric acid (98%)1030kg/t |