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L-ALPHA-PHOSPHATIDYLSERINES, BRAIN

Phosphatidylserine

CAS: 51446-62-9

Molecular Formula: C42H82NO10P

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L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Names and Identifiers

Name Phosphatidylserine
Synonyms Phosphatidylserine
L-ALPHA-PHOSPHATIDYLSERINES, BRAIN
1,2-Distearoyl phosphatidyl serine
1,2-Distearoyl-sn-3-glycerophosphoserine
1,2-Distearoyl-sn-glycero-3-phosphatidylserine
CAS 51446-62-9

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Physico-chemical Properties

Molecular FormulaC42H82NO10P
Molar Mass792.07
Density1.039±0.06 g/cm3(Predicted)
Boling Point816.3±75.0 °C(Predicted)
Solubility Emulsified in water, insoluble in ethanol, methanol; soluble in chloroform, ether, petroleum ether.
AppearanceLight yellow or yellow powder or solid
Storage Condition-20 ℃, nitrogen storage
Physical and Chemical PropertiesPhysical and chemical properties of pure PS white waxy solid, soluble in water containing a small amount of most non-polar solvent, insoluble in anhydrous acetone, chloroform methanol extraction method can be used to extract from tissue cells. When PS is dissolved in water, most insoluble lipids form micelles, with the exception of very few true solutions. At pH 7, PS has two negative charges and one positive charge, and the net negative charge remains. Hydrolysis with a weak base produces a metal chemical salt of a fatty acid, the remainder of which is not hydrolyzed; Hydrolysis with a strong base produces fatty acids, serine, and glycerophosphate. PS exposure to air is easy to be oxidized, the color gradually darkened, from white to yellow, and finally black. The natural state of PS is almost not affected by alcohol, saturated PS and alcohol form cross-chain gel, the interaction of dipalmitoyl-phosphatidylserine with 5% alcohol induces the formation of a regular gel at room temperature.

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Reference

Reference
Show more
1. Jia Shouning, Sun Mengru, Ma Chunhua, etc. Effects of salidroside on structure and function of erythrocyte membrane in rats with high altitude polycythemia [J]. Chinese Herbal Medicine, Volume 51, 15, 2020, pages 3960-3967, ISTIC PKU CSCD CA, 2020.

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Central nervous effects of phosphatidylserine

from VIP Journal Professional Edition

Author:

Song Shulang , keaiguo

Abstract:

phosphatidylserine is an important cell membrane active component, which can affect a variety of biological changes in the nervous system. This paper introduces the biochemical effects of phosphatidylserine, pharmacological effects on the central nervous system and its mechanism of action, the purpose is to summarize the current understanding of phosphatidylserine, promote the study of its physiology and pharmacology.

Key words:

phosphatidylserine Central nervous system pharmacological effects mechanism of action

DOI:

10.3969/j.issn.1005-1678.2006.02.019

cited:

44

year:

2006

Last Update：2024-01-02 23:10:35

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Binding activity of Annexin B1 to phosphatidylserine

from VIP

Author:

Wang Fang , Zhang yi , Hongli Yan , High-distance ship , Liu Fan , He Yan , Sun Shuhan

Abstract:

Objective: to study the binding activity of annexin B1 to phosphatidylserine. Methods: annexin B1 protein was expressed in E. Coli and purified product was obtained by ion exchange chromatography. U937 cells were used to prepare washed platelets by hydrogen peroxide and activated by thrombin; annexin B1 labeled with fluorescein isothiocyanate (FITC) was used to detect apoptotic cells and activated platelets. Results: FITC-labeled annexin B1 could specifically bind to both apoptotic cells and activated platelets, with binding activity close to annexin V. Conclusion: annexin B1 can bind to phosphatidylserine (PS) on the membrane of apoptotic cells and activated platelets, but not other membrane components, it is further clarified that the anticoagulant function of annexin B1 interferes with the coagulation process by binding to platelet membrane phospholipids.

Key words:

ANNEXIN B1 phosphatidylserine binding activity platelet activation apoptosis

DOI:

10.3321/j.issn:0258-879X.2004.01.012

cited:

30

year:

2004

Last Update：2023-08-16 22:09:08

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Introduction

Phosphatidylserine is also called compound neuronic acid. English name Phosphatidylserine, or PS for short, is extracted from natural soybean oil extraction residues. It is the active substance of the cell membrane, especially in brain cells. Its function is mainly to improve the function of nerve cells, regulate the conduction of nerve impulses, and enhance the memory function of the brain. Because of its strong lipophilicity, it can quickly enter the brain through the blood-brain barrier after absorption, which can relieve vascular smooth muscle cells and increase The role of blood supply to the brain.
Last Update：2022-10-16 17:30:43

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Method for extracting phosphatidylserine from animal brain

from Palm Bridge research

Application (patent) number:

CN 200410024225

application date:

Jun 1, 2004

Public/Announcement Number:

CN 1583766 A

applicant (patent):

Shandong Normal University

inventor:

Yating Yang

National and provincial code:

Shandong

cited:

8

Abstract:

The present invention provides a method for extracting phosphatidylserine from animal brain. First, the dried animal brain is broken into particles, then acetone is added to the particles, and the acetone supernatant containing cholesterol and oil in the dried brain particles is removed by stirring and extracting, and the residue is evaporated to dryness; B. Adding n-hexane or ethanol or ammonia-water-ethanol solution to the evaporated residue, extracting with stirring, removing the extract containing the phospholipid complex, and evaporating the residue to dryness; c. Adding ether to the evaporated residue, stirring and extracting, adding alkaline aqueous solution to the extract after evaporation, stirring, freezing, thawing, filtering out the precipitate, further removing the remaining phospholipids, the supernatant was then adjusted to pH = 3-6, ether was distilled off and evaporated to dryness to give crude phosphatidylserine. Then the crude phosphatidylserine dry powder was dissolved in n-hexane, and then sodium acetate ethanol solution was added, stirred, and the lower layer containing inositol phospholipid was removed, and the upper n-hexane was evaporated under reduced pressure to obtain high purity phosphatidylserine.

expand

sovereignty:

1. A method for extracting phosphatidylserine from animal brain, characterized in that: a, the dried animal brain is first broken into particles, then acetone is added to the granules, and the acetone supernatant containing cholesterol and oil in the dried brain grains is removed by stirring and extracting, and the residue is evaporated to dryness; b, add n-hexane or ethanol or ammonia ethanol solution to the evaporated residue, stir and extract, remove the extract containing phospholipid complex and evaporate the residue to dryness; c, add ether to the evaporated residue, stir extraction, extract by evaporation after adding alkaline aqueous solution, stirring, freezing, thawing, filtering out the precipitate, further remove the remaining phospholipids, the supernatant was then adjusted to PH = 3 ~ 6, ether was distilled off, and dried to obtain crude phosphatidylserine.

Last Update：2023-08-16 22:09:08

L-ALPHA-PHOSPHATIDYLSERINES, BRAIN - Cooperative effects of phosphatidylserine eversion and phospholipid oxidation on clearance of apoptotic cells by phagocytes

from Wanfang Medical

Author:

Wang Yanqun , Liu Shangxi , houffan , Li Zhonghai

Abstract:

to investigate the effect of phosphatidylserine (PS) eversion and phospholipid oxidation on the clearance of apoptotic cells by phagocytic cells, the red blood cell models with different apoptotic signals were prepared by integrating different phospholipids into red blood cells by liposome integration method or pretreatment of red blood cells with N-acetylmaleamide (N-ethylmaleimide,NEM) and then integrating phospholipids, the binding rate and phagocytic rate of macrophages to erythrocytes integrating different phospholipid signals were determined. The results showed that the incorporation of PS alone or treatment with NEM resulted in PS eversion, which could significantly increase the binding rate of macrophages to erythrocytes, but had no effect on the phagocytosis rate; simultaneous integration of PS and oxidized phospholipids (oxidized PS or oxidized phosphatidylcholine (PC)), or treatment with NEM to cause eversion of PS followed by integration of oxidized PS or oxidized PC, not only can significantly improve the binding rate of macrophages to red blood cells, but also can significantly improve the phagocytosis rate. These results suggest that PS eversion may be involved in the binding of macrophages to apoptotic cells, and phospholipid oxidation may initiate the phagocytosis of macrophages to apoptotic cells, the cooperation of the two can complete the removal of apoptotic cells by macrophages.

stowed

Key words:

phosphatidylserine oxidized phospholipids apoptotic cells phagocytosis

DOI:

10.3321/j.issn:1000-6737.2006.02.009

cited:

21

year:

2006

Last Update：2023-08-16 22:09:08
L-ALPHA-PHOSPHATIDYLSERINES, BRAIN
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: L-alpha-Phosphatidyl-L-serine Visit Supplier Webpage Request for quotation
CAS: 51446-62-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Phosphatidylserine Request for quotation
CAS: 51446-62-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Phosphatidylserine Request for quotation
CAS: 51446-62-9
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: Phosphatidylserine Request for quotation
CAS: 51446-62-9
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
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