Name | 4-Butoxyaniline |
Synonyms | AKOS BC-2572 4-Butoxyaniline P-BUTOXYANILINE p-Butoxyaniline Benzenamine, 4-butoxy- LABOTEST-BB LT01143388 |
CAS | 4344-55-2 |
EINECS | 224-402-2 |
InChI | InChI=1/C10H15NO/c1-2-3-8-12-10-6-4-9(11)5-7-10/h4-7H,2-3,8,11H2,1H3 |
Molecular Formula | C10H15NO |
Molar Mass | 165.23 |
Density | 0.999g/cm3 |
Melting Point | 130-132 °C |
Boling Point | 278°C at 760 mmHg |
Flash Point | 123.6°C |
Vapor Presure | 0.00436mmHg at 25°C |
pKa | 5.23±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.53 |
MDL | MFCD00007866 |
Physical and Chemical Properties | Chemical properties Boiling point 132 ℃(0.53kPa). The boiling point of industrial products with 97% purity is 148-149 ℃(13mmHg), the relative density is 0.992, the refractive index is 1.5343, and the flash point is> 110 ℃. |
Use | Uses pharmaceutical intermediates. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | 2810 |
WGK Germany | 3 |
RTECS | BW9420000 |
TSCA | Yes |
HS Code | 29214200 |
Hazard Class | 6.1 |
Packing Group | III |
Raw Materials | Sodium sulfide Sodium bromide 1-Bromobutane Sodium 4-nitrophenoxide 4-N-BUTOXYNITROBENZENE |
Downstream Products | 4-N-BUTOXYBENZONITRILE |
Specific gravity | approximate 1 |
BRN | 2084421 |
NIST chemical information | Benzenamine, 4-butoxy-(4344-55-2) |
EPA chemical information | Benzenamine, 4-butoxy- (4344-55-2) |
Hazard Note | Irritant |
It is obtained by alkylation and reduction of sodium p-nitrophenol. 1. Hydrocarbonation Add sodium p-nitrophenol and bromobutane to ethanol for heating and reflux. After 4 hours of reaction, heat preservation reaction is carried out for 16 hours. Then the temperature is cooled to below 75 ℃ and filtered, the filtrate is recovered from ethanol, and the remaining liquid is washed with water to remove water to obtain oily p-nitrophenyl butyl ether. 2. Reduction: First, sulfur and sodium sulfide are added to water for heating and dissolution, p-nitrophenyl butyl ether is added in batches, and the temperature is kept at 138-140 ℃ for 16 hours. Cool down to below 130 ℃, add water and stir, then stand and delaminate. The water layer is discarded, the oil layer is filtered and then distilled under reduced pressure, and the fraction at 144-146 ℃(1.33kPa) is collected to obtain p-aminophenyl butyl ether.